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Cancer has become the leading cause of death in developing countries due to increased life expectancy of the population and changes in lifestyle. Studies on active principles of plant have motivated researchers to develop new antitumor agents that are specific and effective for treatment of neoplasms. Kaurane diterpenes are considered important compounds in(More)
Croton antisyphiliticus is a medicinal plant widely used in the treatment of microbial infections, especially those affecting the genital tract. Crude extract, fractions and pure compound isolated from roots of this species were investigated to validate their antimicrobial activity against Escherichia coli and Staphylococcus aureus. The compound(More)
We have investigated the in vitro anticandidal and antioxidant activities of phenolic compounds from Pyrostegia venusta flower extracts. We used the HPLC technique to purify the flavonoid (quercetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside) and two phenylpropanoid glycosides (verbascoside and isoverbascoside); we evaluated the antimicrobial(More)
The use of elicitors has become a valuable strategy to enhance the production of plant bioactive compounds. In this work jasmonic acid solutions and extracts containing jasmonates produced by Botryosphaeria rhodina were used to elicit coumarin accumulation in Mikania laevigata. Plants cultured inside a greenhouse under monitored environmental conditions(More)
Introduction: Nowadays Alzheimer's disease is the leading cause of dementia in the world. The major neuropathological signs of this disease include the formation of neurofibrillary tangles, extracellular deposition of Aβ peptide and extensive neuronal loss. Aβ peptide accumulation seems to be the initial factor of degeneration associated to this disease,(More)
The Aβ peptide-mediated toxicity participates in the neuronal death that occurs in Alzheimer's disease. The present study aims to isolate the major compounds of Serjania erecta Radlk leaves and assess whether these compounds protect PC12 cells from Aβ25-35 peptide-induced toxicity. We isolated three flavonoid glycosides with high purity: quercetrin,(More)
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