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The protein tyrosine kinase p59fyn (Fyn) plays important roles in both lymphocyte Ag receptor signaling and cytokinesis of proB cells. We utilized yeast two-hybrid cloning to identify the product of the tctex-1 gene as a protein that specifically interacts with Fyn, but not with other Src family kinases. Tctex-1 was recently identified as a component of the(More)
BACKGROUND Clinical laboratory reference intervals have not been established in many African countries, and non-local intervals are commonly used in clinical trials to screen and monitor adverse events (AEs) among African participants. Using laboratory reference intervals derived from other populations excludes potential trial volunteers in Africa and makes(More)
BACKGROUND An understanding of the health of potential volunteers in Africa is essential for the safe and efficient conduct of clinical trials, particularly for trials of preventive technologies such as vaccines that enroll healthy individuals. Clinical safety laboratory values used for screening, enrolment and follow-up of African clinical trial volunteers(More)
The glutamate system includes presynaptic glutamatergic terminals, complex post-synaptic densities found on diverse types of neurons expressing glutamate receptors, as well as glutamate transporters and enzymes that facilitate the glutamate/glutamine cycle. Abnormalities of this system have been implicated in schizophrenia based on an accumulating body of(More)
Acknowledgments Grants from the Agricultural Development Board through the Kentucky Horticulture Council have allowed an expansion of the field research and demonstration program to meet the informational and educational needs of our growing vegetable and fruit industries. Important note to readers: The majority of research reports in this volume do not(More)
Acknowledgments Grants from the Agricultural Development Board through the Kentucky Horticulture Council have allowed an expansion of the field research and demonstration program to meet the informational and educational needs of our growing vegetable and fruit industries. Important note to readers: The majority of research reports in this volume do not(More)
Acknowledgments Grants from the Agricultural Development Board through the Kentucky Horticulture Council have allowed an expansion of the field research and demonstration program to meet the informational and educational needs of our growing vegetable and fruit industries. Important note to readers: The majority of research reports in this volume do not(More)
  • Chris Smigell, Doug Archbold, +59 authors Emine Bayar
  • 2008
Acknowledgments Grants from the Agricultural Development Board through the Kentucky Horticulture Council have allowed an expansion of the field research and demonstration program to meet the informational and educational needs of our growing vegetable and fruit industries. Important note to readers: The majority of research reports in this volume do not(More)
Beta-Bungarotoxin (beta-BuTX) and notexin are phospholipase A2 (PLA2) neurotoxins which cause an irreversible blockade of neurotransmitter release through specific and potent effects at the presynaptic nerve terminal; however, their mechanism of action is uncertain. We examined the effects of beta-BuTX and notexin on Na+/K+ ATPase activity using(More)
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