Irene Griswold-Prenner7
Christine E Brown3
Stephen J Forman3
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Several neurological diseases, including Parkinson disease and dementia with Lewy bodies, are characterized by the accumulation of alpha-synuclein phosphorylated at Ser-129 (p-Ser-129). The kinase or kinases responsible for this phosphorylation have been the subject of intense investigation. Here we submit evidence that polo-like kinase 2 (PLK2, also known(More)
Pathological hallmarks of Alzheimer's disease are the presence of extracellular amyloid plaques, intracellular neurofibrillary tangles, and neurodegeneration. The principal component of amyloid plaques is the amyloid-beta peptide (Abeta). Accumulating evidence indicates that Abeta may play a causal role in Alzheimer's disease. In this report, we demonstrate(More)
Accumulating evidence suggests that amyloid protein aggregation is pathogenic in many diseases, including Alzheimer's disease. However, the mechanisms by which protein aggregation mediates cellular dysfunction and overt cell death are unknown. Recent reports have focused on the potential role of amyloid oligomers or protofibrils as a neurotoxic form of(More)
Beta-amyloid (Abeta) is the principal component of the extracellular plaques present in patients with Alzheimer's disease. Several studies have recently shown that acutely applied Abeta inhibits the induction of LTP in the hippocampus. In the present studies, we have investigated the role of integrins in such Abeta-mediated block of LTP in the dentate gyrus(More)
or casein kinase 2 was incubated with 27mM Hepes, pH 7.5, 1mM MgCl2, 10µCi/nmole 32 P-γ-ATP (Perkin Elmer), 1µM casein (Sigma), 40mM nitrophenylphosphate (Sigma), and 100µM orthovanadate (Sigma), at 30ºC for 2 hours. Reactions were stopped with SDS-PAGE sample buffer, and loaded onto 10-20% Tricine gels (Invitrogen). After separating the proteins, the gels(More)
Amyloid-β (Aβ) peptide is a key component of amyloid plaques, one of the pathological features of Alzheimer's disease. Another feature is pronounced cell loss in the brain leading to an enlargement of the ventricular area and a decrease in brain weight and volume. Aβ plaque deposition and neuronal toxicity can be modeled by treating human cortical neuronal(More)
  • Research Showcase, Cmu, Nicole Hassoun, Leif Wenar, Darrel Moellendorf, Bill Oberdick +17 others
  • 2015
what should environmentalists say about free trade? Many environmentalists object to free trade by appealing the " Race to the Bottom Argument. " This argument is inconclusive, but there are reasons to worry about unrestricted free trade's environmental effects nonetheless; the rules of trade embodied in institutions such as the World Trade Organization may(More)
The interaction of amyloid-beta (Aβ) and tau in the pathogenesis of Alzheimer's disease is a subject of intense inquiry, with the bulk of evidence indicating that changes in tau are downstream of Aβ. It has been shown however, that human tau overexpression in amyloid precursor protein transgenic mice increases Aβ plaque deposition. Here, we confirm that(More)
In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: Abstract In September 2005, the Pacific Islands Forum issued a finalized Pacific Plan.(More)