Sarah Warburton

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PURPOSE Melanolipofuscin (MLF) is a complex granule, exhibiting properties of both melanosomes and lipofuscin (LF) granules, which accumulates in retinal pigment epithelial (RPE) cells and may contribute to the etiology of age-related macular degeneration (AMD). MLF accumulation has been reported by Feeney-Burns to more closely reflect the onset of AMD than(More)
Ligand-gated ion channels underlie synaptic communication in the nervous system(1). In mammals there are three families of ligand-gated channels: the cys loop, the glutamate-gated and the P2X receptor channel family(2). In each case binding of transmitter leads to the opening of a pore through which ions flow down their electrochemical gradients. Many(More)
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