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  • Jack D Scott, Sarah W. Li, +27 authors Andrew W. Stamford
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 8 December 2016
  • Verubecestat 3 (MK-8931), a diaryl amide-substituted 3-imino-1,2,4-thiadiazinane 1,1-dioxide derivative, is a high-affinity β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitorContinue Reading
  • Jack D Scott, Duane Demong, +42 authors Michael W. Miller
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 13 April 2017
  • Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein which contains a kinase domain and GTPase domain among other regions. Individuals possessing gain of function mutations in theContinue Reading