Sarah Tempelaar

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The ring-opening polymerisation of lactide by a range of amino-oxazoline and amino-thiazoline catalysts is reported. The more electron-rich derivatives are demonstrated to be the most highly active and polymerisation is well controlled, as evidenced by the linear relationship between the molecular weight and both the monomer conversion and the(More)
Owing to their low toxicity, biocompatibility and biodegradability, aliphatic poly(carbonate)s have been widely studied as materials for biomedical application. Furthermore, the synthetic versatility of the six-membered cyclic carbonates for the realization of functional degradable polymers by ring-opening polymerisation has driven wider interest in this(More)
RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. In an effort to provide a safe alternative to PEI, we have designed a series of new guanidinium- and morpholino-functionalized biocompatible and biodegradable polycarbonate vectors. The impact of different functions (morpholino-, guanidinium-, hydrophobic(More)
RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. To meet the challenge of gene therapy and deliver small-interfering RNA (siRNA) into the cytoplasm of target cells, several barriers must be overcome. The most widely used polymeric vector is polyethylenimine (PEI) but its cytotoxicity limits its use in(More)
Advanced organocatalytic synthesis methods were employed to prepare linear poly(carbonate)s with control over functional group incorporation and molecular weight. Pendant allyl or epoxide groups served as reaction partners in thiol-ene click or epoxide-amine reactions with ethylene oxide-containing crosslinking groups to form a panel of six novel(More)
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