Sarah Phelps

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BACKGROUND Airway inflammation in asthma is associated with cysteinyl leukotriene and prostaglandin D(2) production. Measurement of urinary metabolites of these eicosanoids may be useful for monitoring asthma patients. However, the influence of asthma phenotype and severity on basal urinary excretion of these metabolites is unknown. OBJECTIVE To compare(More)
STUDY OBJECTIVES To retrospectively determine the 6-year cumulative incidence rate of firearm mortality and estimate nonfatal firearm injuries in Connecticut. METHODS Retrospective analysis of data originating from the Connecticut State Medical Examiner's Office and records from the Trauma Registry of one urban hospital. RESULTS From January 1988(More)
OBJECTIVE To describe clinical characteristics associated with analgesia utilization in the intensive care unit. DESIGN A prospective cohort study of adult patients admitted to a medical intensive care unit. SUBJECTS Four hundred adult patients. SETTING Twelve-bed medical intensive care unit of an inner-city, university-affiliated hospital. (More)
BACKGROUND The cysteinyl-leukotrienes (cys-LTs) are important pro-inflammatory mediators in asthma, and have been shown to have a role in specific disease subtypes, including asthma severity. Few studies have investigated the role of polymorphisms in the ALOX5AP gene, encoding 5-lipoxygenase activating protein (FLAP), and asthma. We hypothesized that(More)
BACKGROUND IL-16 is an immunomodulatory cytokine whose expression is increased in the bronchial mucosa, bronchoalveolar lavage fluid and induced sputum of asthmatic patients. It has been suggested that IL-16 has a regulatory role in the pathophysiology of asthma. A single-nucleotide polymorphism (T(-295)C) has been described in the promoter region of the(More)
Synovial sarcoma most commonly affects adults in the third to fifth decades of life, and is the most common sarcoma of the foot. The tumors are encapsulated and frequently in contact with bone. Because there are often few anatomical barriers, malignant spread to surrounding nerves and vasculature is common. This article discusses the case of a young patient(More)
(" AAMC "), the Graduate Management Admission Council (" GMAC "), and the participating individual universities make the following disclosures: 1. ACE is a non-profit association. ACE is not a publicly held corporation or other publicly held entity. It does not have any parent corporation, it has not issued any stock, and there is no publicly-held(More)
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