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OBJECTIVE To investigate sexual function in women with complete androgen insensitivity syndrome (CAIS) and to investigate the prevalence of factors that might contribute to sexual difficulties. DESIGN Cross sectional survey and clinical examination. SETTING Tertiary hospital multidisciplinary intersex clinic and an international peer support group for(More)
OBJECTIVE To describe variations in genital dimensions of normal women. DESIGN Observational cross-sectional study. SETTING Elizabeth Garrett Anderson Hospital, University College Hospital NHS Trust, London, UK. POPULATION Fifty premenopausal women having gynaecological procedures not involving the external genitalia under general anaesthetic. (More)
Reconstructive surgery has been the traditional treatment for the short vagina. Recently vaginal dilation has been recommended due to its low morbidity. Small retrospective studies have reported success rates of up to 80% but include neither clear definitions of "success" nor exploration of factors associated with compliance and outcome. The first 10 women(More)
BACKGROUND Various surgical and non-surgical treatment options are available for women with congenital vaginal agenesis. We report results of vaginal dilation therapy delivered by a multi-disciplinary team as first line treatment for vaginal agenesis. METHODS Twenty-six women were recruited into a prospective observational study: 18 had(More)
Predictive and pre-natal testing for Huntington's Disease (HD) has been available since 1987. Initially this was offered by linkage analysis, which was surpassed by the advent of the direct mutation test for HD in 1993. Direct mutation analysis provided an accurate test that not only enhanced predictive and pre-natal testing, but also permitted the(More)
OBJECTIVE The objective of the study was to investigate health, well-being, and sexual function in women with Rokitansky syndrome. STUDY DESIGN Fifty-eight women with Rokitansky syndrome completed 4 questionnaires assessing health-related quality of life, emotional distress, and sexual function and attended for a vaginal examination. RESULTS(More)
INTRODUCTION AND HYPOTHESIS Congenital vaginal aplasia is a condition with devastating implications for fertility and sexuality. However, little is known on whether urinary symptomatology is more common prior and following vaginal lengthening procedures in these women. METHODS We performed a prospective observational study of 19 women with vaginal(More)
Autism Spectrum Disorders (ASDs) are complex neurodevelopmental disorders with many biological causes, including genetic, syndromic and environmental. Such etiologic heterogeneity impacts considerably upon parents' needs for understanding their child's diagnosis. A descriptive survey was designed to investigate parental views on the cause(s) of ASD in their(More)
OBJECTIVE To assess clinical characteristics and expectations in well women requesting elective labial reduction surgery. DESIGN Prospective study of women attending an outpatient gynaecology clinic. SETTING General gynaecology clinic at a Central London teaching hospital. SAMPLE Women requesting labial reduction surgery and referred by their general(More)
OBJECTIVES To determine the frequency and severity of endometriosis in adolescent and teenager girls with chronic pelvic pain (CPP) who fail to respond to medical treatment and to evaluate the outcome of radical laparoscopic surgery for severe endometriosis. DESIGN Retrospective review of case records of all girls under the age of 21 years who underwent(More)