Sarah M. Woods

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Mutations of the isocitrate dehydrogenase 1 (IDH1) gene are among the most prevalent in low-grade glioma and secondary glioblastoma, represent an early pathogenic event, and are associated with epigenetically driven modulations of metabolism. Of particular interest is the recently uncovered relationship between the IDH1 mutation and decreased activity of(More)
Activation of the PI3K/Akt pathway is associated with the development of numerous human cancers. As a result, many emerging therapies target this pathway. Previous studies have shown that targeting the PI3K/Akt pathway at the level of PI3K is associated with a drop in phosphocholine (PCho) and a reduction in hyperpolarized lactate production. However, the(More)
Myriam M. Chaumeil, Peder E.Z. Larson, Sarah M. Woods, Larry Cai, Pia Eriksson, Aaron E. Robinson, Janine M. Lupo, Daniel B. Vigneron, Sarah J. Nelson, Russell O. Pieper, Joanna J. Phillips, Sabrina M. Ronen 1 Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street San Francisco 94158, CA, USA 2 Department of(More)
Metabolic reprogramming is increasingly being viewed as a hallmark of cancer. Accordingly, metabolic readouts can serve as biomarkers of response to therapy. The goal of this study was to investigate some of the MRS-detectable metabolic consequences of mitogen-activated protein kinase kinase (MEK) inhibition. We investigated PC3 prostate cancer, MCF-7(More)
Alterations in cell metabolism are increasingly being recognized as a hallmark of cancer and are being exploited for the development of diagnostic tools and targeted therapeutics. Recently, ¹³C MRS-detectable hyperpolarized pyruvate to lactate conversion has been validated in models as a noninvasive imaging method for the detection of tumors and treatment(More)
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