Sarah M. Strong

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A prospective randomized study was conducted to determine the relative effectiveness, toxicity and tolerance of methotrexate (MTX) versus cisplatin (DDP) in patients with recurrent head and neck squamous cell carcinoma. Forty-four patients were randomized to receive either MTX, 40 mg escalated to 60 mg/m2 IV push weekly, or DDP, 50 mg/m2 6 hour infusion(More)
In a series of 51 cases of Stage IV head and neck carcinomas, 12 selected patients were studied retrospectively, in order to determine the role of surgery in their management. Two patients who received a tumoricidal dose of radiation prior to radical neck dissection survived over five years, but no viable tumor was found in either specimen, suggesting a(More)
Ten patients with advanced or recurrent squamous cell carcinomas of the upper airway were treated with a combination of carbon dioxide laser surgery and radiation therapy to evaluate the tolerance to rapid sequencing of both modalities in a variety of clinical situations. Other considerations were to accurately stage infiltrating tumors, to provide(More)
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