Sarah M. Muller

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Damage resulting from a partial acute lesion of white matter in the central nervous system (CNS) gradually spreads also to neurons that escaped the primary injury, resulting in their degeneration. Such spreading has been referred to as secondary degeneration. In order to demonstrate that this degeneration is indeed secondary to that caused by the acute(More)
As a follow-on from a previous study by Miller, Kris and Griffiths (1997, Optom. Vis. Sci. 84, 521-526), we investigated the effect of small prescription errors on spatial visual performance and spectacle lens acceptability. We included both negative and positive errors and binocular and monocular errors. Data were collected on 15 young adult subjects.(More)
Both mood and cognitive function are altered in cold environments. Body warming through exercise may improve Stroop interference score and lessen total negative mood. The purpose of this study was to determine the effect of equal caloric bouts of interval (INT) and continuous (CONT) exercise on mood and selective attention in the cold. Eleven young men(More)
Military and factory work often involves exposure to cold temperatures. With prolonged exposure, individuals report feeling cold and develop pain in their hands, both of which might be alleviated by endogenous heat production via exercise. The purpose of this study was to evaluate how interval (INT) and continuous (CONT) cycle ergometry alter thermal(More)
We previously reported that continuous 24-month costimulation blockade by abatacept significantly slows the decline of β-cell function after diagnosis of type 1 diabetes. In a mechanistic extension of that study, we evaluated peripheral blood immune cell subsets (CD4, CD8-naive, memory and activated subsets, myeloid and plasmacytoid dendritic cells,(More)
In the cold, Purdue Pegboard (PP) performance declines. The purpose of this study was to determine if this cold-induced impairment is consistent across days (i.e. test-retest reliability) in 5°C. In thermoneutral air (25°C), 14 men were familiarised to the dominant hand (PPa) and bimanual (PPb) PP tasks. They then experienced two 90-min cold exposures (Day(More)
We sought to determine if cold acclimatized men display higher economy (i.e. lower oxygen consumption at a given workload) during graded cycle ergometry in the cold (5°C). After completing a familiarization trial 1 week prior, five cold weather athletes (CWA) and eight physically active men (NON) underwent graded exercise tests to volitional fatigue in 5°C.(More)
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