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Arborization of Dendrites by Developing Neocortical Neurons Is Dependent on Primary Cilia and Type 3 Adenylyl Cyclase
The formation of primary cilia is a highly choreographed process that can be disrupted in developing neurons by overexpressing neuromodulatory G-protein-coupled receptors GPCRs or by blockingExpand
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Development and distribution of neuronal cilia in mouse neocortex
Neuronal primary cilia are not generally recognized, but they are considered to extend from most, if not all, neurons in the neocortex. However, when and how cilia develop in neurons are not known.Expand
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Detection of primary cilia in human glioblastoma
Abstract Glioblastoma (GBM) is the most common malignant adult brain tumor and carries a poor prognosis due to primary and acquired resistance. While many cellular features of GBM have beenExpand
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Influences of Primary Cilia on Cortical Morphogenesis and Neuronal Subtype Maturation
Recognition that virtually every neuronal progenitor cell and neuron in the cerebral cortex is ciliated has triggered intense interest in neuronal cilia function. Here, we review recent studies thatExpand
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Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia
The primary cilia of forebrain neurons assemble around birth and become enriched with neuromodulatory receptors. Our understanding of the permanence of these structures and their associated signalingExpand
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Dcdc 2 knockout mice display exacerbated developmental disruptions following knockdown of Dcx
The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration and differentiation. Here we report the first phenotypic analysis ofExpand
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A model of neocortical area patterning in the lissencephalic mouse may hold for larger gyrencephalic brains
In the mouse, two telencephalic signaling centers orchestrate embryonic patterning of the cerebral cortex. From the rostral patterning center in the telencephalon, the Fibroblast Growth Factor, FGF8,Expand
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Cilia on the Brain: Primary Cilia and Their Roles in Brain Function
The primary cilium was first discovered over 100 years ago but only relatively recently has it been widely regarded as an integral cellular organelle for brain development, maturation and function.Expand