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- Publications
- Influence
Arborization of Dendrites by Developing Neocortical Neurons Is Dependent on Primary Cilia and Type 3 Adenylyl Cyclase
- Sarah M Guadiana, S. Semple-Rowland, +4 authors M. Sarkisian
- Biology, Medicine
- The Journal of Neuroscience
- 6 February 2013
The formation of primary cilia is a highly choreographed process that can be disrupted in developing neurons by overexpressing neuromodulatory G-protein-coupled receptors GPCRs or by blocking… Expand
Development and distribution of neuronal cilia in mouse neocortex
- J. Arellano, Sarah M Guadiana, Joshua J. Breunig, P. Rakic, M. Sarkisian
- Biology, Medicine
- The Journal of comparative neurology
- 1 March 2012
Neuronal primary cilia are not generally recognized, but they are considered to extend from most, if not all, neurons in the neocortex. However, when and how cilia develop in neurons are not known.… Expand
Detection of primary cilia in human glioblastoma
- M. Sarkisian, Dorit Siebzehnrubl, +9 authors B. Reynolds
- Biology, Medicine
- Journal of Neuro-Oncology
- 9 February 2014
Abstract
Glioblastoma (GBM) is the most common malignant adult brain tumor and carries a poor prognosis due to primary and acquired resistance. While many cellular features of GBM have been… Expand
Influences of Primary Cilia on Cortical Morphogenesis and Neuronal Subtype Maturation
- M. Sarkisian, Sarah M Guadiana
- Biology, Medicine
- The Neuroscientist : a review journal bringing…
- 1 April 2015
Recognition that virtually every neuronal progenitor cell and neuron in the cerebral cortex is ciliated has triggered intense interest in neuronal cilia function. Here, we review recent studies that… Expand
Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia
- Sarah M Guadiana, Alexander K. Parker, +7 authors M. Sarkisian
- Biology, Medicine
- Front. Aging Neurosci.
- 31 May 2016
The primary cilia of forebrain neurons assemble around birth and become enriched with neuromodulatory receptors. Our understanding of the permanence of these structures and their associated signaling… Expand
Dcdc 2 knockout mice display exacerbated developmental disruptions following knockdown of Dcx
- Yu Wang, Xiuyin Yin, +6 authors J. Loturco
- 2011
The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration and differentiation. Here we report the first phenotypic analysis of… Expand
- 3
A model of neocortical area patterning in the lissencephalic mouse may hold for larger gyrencephalic brains
- W. D. Jones, Sarah M Guadiana, E. Grove
- Biology, Medicine
- The Journal of comparative neurology
- 6 February 2019
In the mouse, two telencephalic signaling centers orchestrate embryonic patterning of the cerebral cortex. From the rostral patterning center in the telencephalon, the Fibroblast Growth Factor, FGF8,… Expand
Cilia on the Brain: Primary Cilia and Their Roles in Brain Function
- Sarah M Guadiana, E. Grove
- Biology
- 16 February 2015
The primary cilium was first discovered over 100 years ago but only relatively recently has it been widely regarded as an integral cellular organelle for brain development, maturation and function.… Expand