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Antibody Responses to Zika Virus Infections in Environments of Flavivirus Endemicity
TLDR
The potential impact of exposure to related viruses on the outcome of ZIKV infection is illustrated and considerations for development of vaccines and diagnostics are offered. Expand
Human Survivors of Disease Outbreaks Caused by Ebola or Marburg Virus Exhibit Cross-Reactive and Long-Lived Antibody Responses
TLDR
Based on results revealed by the protein microarray, persistent levels of antibodies to GP, NP, and VP40 were maintained for up to 14 years after infection, and survival of infection caused by one species imparted cross-reactive antibody responses to other filoviruses. Expand
Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages
TLDR
It is suggested that alphavirus structural protein microarrays can distinguish infections caused by MAYV, VEEV, and CHIKV and that this multiplexed serological platform could be useful for high-throughput disease surveillance. Expand
Extensive Antibody Cross-reactivity among Infectious Gram-negative Bacteria Revealed by Proteome Microarray Analysis *
TLDR
A microarray comprising ∼70% of the 4066 proteins contained within the Yersinia pestis proteome was developed to identify antibody biomarkers distinguishing plague from infections caused by other bacterial pathogens that may initially present similar clinical symptoms. Expand
Proteomic Basis of the Antibody Response to Monkeypox Virus Infection Examined in Cynomolgus Macaques and a Comparison to Human Smallpox Vaccination
TLDR
Comparing antibody responses to monkeypox virus infection and human smallpox vaccination is compared by using a protein microarray covering 92–95% of representative proteomes from monkeypox viral clades of Central and West Africa, including 92% coverage of the vaccinia virus proteome as a reference orthopox vaccine. Expand
Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases
TLDR
Analysis of peptide dephosphorylation by hierarchical clustering indicated that DUSPs could be organized by substrate sequence motifs, and peptide-specificities by phylogenetic relationships among the catalytic domains. Expand
Analysis of the human immune response to vaccinia by use of a novel protein microarray suggests that antibodies recognize less than 10% of the total viral proteome
TLDR
A protein microarray of the vaccinia virus proteome was developed by using high‐throughput baculovirus expression and purification of individual elements and suggested that proteins recognized by antibodies from all vaccinees constituted <10% of the total vaccinia proteome. Expand
Human Antibody Responses to the Polyclonal Dryvax Vaccine for Smallpox Prevention Can Be Distinguished from Responses to the Monoclonal Replacement Vaccine ACAM2000
TLDR
Analysis of protein sequences fromdryvax clones revealed amino acid level differences in these 11 antigenic proteins and suggested that sequence variation and clonal heterogeneity may contribute to the observed differences between Dryvax and ACAM2000 antibody responses. Expand
Antibiotic‐dependent perturbations of extended spectrum beta‐lactamase producing Klebsiella pneumoniae proteome
TLDR
An overview of the global proteome changes occurring in ESBL‐KP in response to sub‐lethal concentrations of the antibiotics doxycycline and streptomycin, which both impair ribosomal synthesis of bacterial proteins is provided. Expand
Impact of Dengue Virus Serotype 2 Strain Diversity on Serological Immune Responses to Dengue.
TLDR
The striking impact of E diversity on polyclonal immune responses suggests that frequent antigen updates may be necessary for vaccines to counter shifts in circulating strains. Expand
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