Sarah L. Owens

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We determined the visual prognosis of 94 eyes in 92 patients having age-related macular degeneration, a discrete choroidal neovascular membrane directly under the center of the foveal avascular zone (subfoveal), and an initial visual acuity of 20/100 or better. Of the patients who were reexamined 24 months following their initial presentation, 77% had lost(More)
PURPOSE To describe fundus autofluorescence (AF) patterns and their change over time in patients with age-related macular degeneration (AMD) and high risk of visual loss participating in the drusen laser study (DLS). DESIGN Randomized clinical trial. METHODS The study population consisted of 29 patients (35 eyes) participating in the DLS, which is a(More)
This study examined patterns, potential predictors, and outcomes of immunosuppressive medication adherence in a convenience sample of 121 kidney transplant recipients aged 21 yr or older from three kidney transplant centers using a theory-based, descriptive, correlational, longitudinal design. Electronic monitoring was conducted for 12 months using(More)
BACKGROUND In previous natural history studies and clinical trials, AIDS-related cytomegalovirus (CMV) retinitis has occurred primarily in patients with absolute CD4 counts of 50 cells/microL or less (0.05 x 10(9)/L) at the time of diagnosis. METHODS We report five patients identified from our clinical practices who were diagnosed with CMV retinitis while(More)
Cytomegalovirus (CMV) disease is a common complication of advanced human immunodeficiency virus (HIV) infection. Administration of oral valaciclovir, a valine ester of acyclovir, achieves sufficient plasma acyclovir levels to inhibit many clinical isolates. Acyclovir has been associated with enhanced survival in AIDS but not with CMV disease prevention.(More)
The Wilmer Retinal Vascular Center's experience with central serous chorioretinopathy from 1970 to the end of 1979 was reviewed and compared with previous studies. Retrospective analysis of 73 patients seen at follow-up suggests no clinically significant effect of focal argon laser photocoagulation on final visual acuity or recurrence rate. Patients with(More)
Of 89 patients with idiopathic preretinal gliosis examined between 1970 and 1978, 52 were examined within six months of the onset of symptoms. Forty-seven patients were men and 42 were women; 83 (93%) were more than 50 years old. Initial visual acuities were 6/12 (20/40) or better in 60 of 98 eyes (61%). Nine patients had initial bilateral involvement, and(More)
A brief survey of the recent ophthalmic literature underscores a resurgence of interest in indocyanine green angiography (ICGA). This imaging method may be particularly useful for the ophthalmologist, as it provides at least a theoretical advantage for improved imaging of the choroidal circulation when compared with fluorescein angiography. New temporal and(More)
Background: Abnormalities of dark adaptation have been documented in patients with age-related macular degeneration (AMD), but the relationship with the various forms of this disorder has not been studied systematically. Methods: Dark-adapted retinal sensitivities and kinetics of dark adaptation were studied using a Humphrey visual field analyzer adapted(More)
PURPOSE To describe cytomegalovirus (CMV) end-organ disease (EOD) rate in AIDS patients with low CD4+ cell count despite HAART who were enrolled in a randomized, placebo-controlled trial of preemptive valganciclovir (VGCV) to prevent CMV EOD in those with CMV viremia. METHODS Subjects (N = 338) were HIV-infected with CD4+ count <100 cells/mm3, plasma HIV(More)