Sarah Löw

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OBJECT The authors have previously reported that erlotinib, an EGFR tyrosine kinase inhibitor, exerts widely variable antiproliferative effects on 9 human glioblastoma multiforme (GBM) cell lines in vitro and in vivo. These effects were independent of EGFR baseline expression levels, raising the possibility that more complex genetic properties form the(More)
Human glioblastomas may be hierarchically organized. Within this hierarchy, glioblastoma-initiating cells have been proposed to be more resistant to radiochemotherapy and responsible for recurrence. Here, established stem cell markers and stem cell attributed characteristics such as self-renewal capacity and tumorigenicity have been profiled in primary(More)
—Developing, maintaining and operating large IT– systems is a complex and challenging task. Model–driven approaches can help to manage this complexity. However, during the life time of a system the models are not static but evolve through adaption to system changes or extensions. Therefore also models have to be organised and stored in a structured way. A(More)
BACKGROUND The purpose of this study was to determine the relevance of clinical data, apparent diffusion coefficient (ADC), and relative cerebral blood volume (rCBV) from dynamic susceptibility contrast (DSC) perfusion and the volume transfer constant (k(trans)) from dynamic contrast-enhanced (DCE) perfusion for predicting overall survival (OS) and(More)
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