Sarah Knepper

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Norepinephrine (NE) and the selective alpha1-adrenoceptor agonist phenylephrine (PE) both markedly stimulate the formation of [3H]inositol phosphates in a concentration-dependent manner upon incubation with [3H]myo-inositol. The selective alpha2 agonist, clonidine, did not significantly alter [3H]inositol phosphate formation, even at concentrations as high(More)
The abilities of several amphetamine analogs with restricted conformations to inhibit uptake of [3H]norepinephrine into synaptic vesicles isolated from rat brain cerebral cortex were compared. [3H]Norepinephrine was accumulated in the vesicles with a Km of 3.5 microM and a Vmax of 7.6 pmol/g of tissue per min. This uptake was inhibited by reserpine (IC50,(More)
A main problem in adaptive optics is to reconstruct the phase spectrum given noisy phase differences. We present an efficient approach to solve the least-squares minimization problem resulting from this reconstruction, using either a truncated singular value decomposition (TSVD)-type or a Tikhonov-type regularization. Both of these approaches make use of(More)
1 Purpose: During a positron emission tomography scan, a patient may move. These movements degrade the reconstructed image, especially as the resolution of the scanner increases. When imaging a rigid object, such as the brain, these movements may be tracked and recorded with fairly high precision. Then, this information may be used in the de-convolution(More)
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