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Polyketides, the ubiquitous products of secondary metabolism in microorganisms, are made by a process resembling fatty acid biosynthesis that allows the suppression of reduction or dehydration reactions at specific biosynthetic steps, giving rise to a wide range of often medically useful products. The lovastatin biosynthesis cluster contains two type I(More)
Lovastatin biosynthesis in Aspergillus terreus involves two unusual type I multifunctional polyketide syntheses (PKSs). Lovastatin nonaketide synthase (LNKS), the product of the lovB gene, is an iterative PKS that interacts with LovC, a putative enoyl reductase, to catalyze the 35 separate reactions in the biosynthesis of dihydromonacolin L, a lovastatin(More)
Mutations in the Streptomyces peucetius dnrD gene block the ring cyclization leading from aklanonic acid methyl ester (AAME) to aklaviketone (AK), an intermediate in the biosynthetic pathway to daunorubicin (DNR) and doxorubicin. To investigate the role of DnrD in this transformation, its gene was overexpressed in Escherichia coli and the DnrD protein was(More)
The adaptive optics system for the second-generation VLT-interferometer (VLTI) instrument GRAVITY consists of a novel cryogenic near-infrared wavefront sensor to be installed at each of the four unit telescopes of the Very Large Telescope (VLT). Feeding the GRAVITY wavefront sensor with light in the 1.4 to 2.4 micrometer band, while suppressing laser light(More)
MIDIR is the proposed thermal/mid-IR imager and spectrograph for the European Extremely Large Telescope (E-ELT). It will cover the wavelength range of 3 to at least 20 µm. Designed for diffraction-limited performance over the entire wavelength range, MIDIR will require an adaptive optics system; a cryogenically cooled system could offer optimal performance(More)
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