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A novel epiphytic cyanobacterium associated with reservoirs affected by avian vacuolar myelinopathy
Avianvacuolar myelinopathy (AVM) is a newly discovered bird disease, which is killing bald eagles (Haliaeetus leucocephalus) and waterfowl in the southeastern United States. Surveys were conducted toExpand
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Effects of glatiramer acetate and interferon-beta on neurodegeneration in a model of multiple sclerosis: a comparative study.
Axonal destruction and neuronal loss occur early during multiple sclerosis (MS), an autoimmune inflammatory central nervous system disease that frequently manifests with acute optic neuritis.Expand
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Effects of interferon-beta-1a on neuronal survival under autoimmune inflammatory conditions
Interferon-beta-1a (IFN-beta-1a) is an approved treatment for multiple sclerosis (MS). It improves the disease course by reducing the relapse rate as well as the persistent neurological deficits.Expand
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Antibody-Mediated Inhibition of TNFR1 Attenuates Disease in a Mouse Model of Multiple Sclerosis
Tumour necrosis factor (TNF) is a proinflammatory cytokine that is known to regulate inflammation in a number of autoimmune diseases, including multiple sclerosis (MS). Although targeting of TNF inExpand
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Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis
The catabolism of tryptophan to immunosuppressive and neuroactive kynurenines is a key metabolic pathway regulating immune responses and neurotoxicity. The rate-limiting step is controlled byExpand
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Calcium influx and calpain activation mediate preclinical retinal neurodegeneration in autoimmune optic neuritis.
Optic neuritis is a common manifestation of multiple sclerosis, an inflammatory demyelinating disease of the CNS. Recently, the neurodegenerative component of multiple sclerosis has come under focusExpand
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INVESTIGATION OF THE LINK BETWEEN AVIAN VACUOLAR MYELINOPATHY AND A NOVEL SPECIES OF CYANOBACTERIA THROUGH LABORATORY FEEDING TRIALS
Avian vacuolar myelinopathy (AVM) is a neurologic disease affecting Bald Eagles (Haliaeetus leucocephalus), American Coots (Fulica americana), and other birds in the southeastern United States. TheExpand
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Role of n‐type voltage‐dependent calcium channels in autoimmune optic neuritis
The aim of this study was to investigate the role of voltage‐dependent calcium channels (VDCCs) in axon degeneration during autoimmune optic neuritis.
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Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis.
Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system that results in persistent impairment in young adults. During chronic progressive disease stages, there is aExpand
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Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease
Neuronal subpopulations display differential vulnerabilities to disease, but the factors that determine their susceptibility are poorly understood. Toxic increases in intracellular calcium are a keyExpand
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