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A Small Molecule Inhibitor of ETV1, YK-4-279, Prevents Prostate Cancer Growth and Metastasis in a Mouse Xenograft Model
YK-4-279 is a potent inhibitor of ETV1 and inhibits both the primary tumor growth and metastasis of fusion positive prostate cancer xenografts and may be evaluated as a potential therapeutic tool for treatment of human prostate cancer at different stages.
Abstract 5453: YK-4-279 inhibits ETS-positive prostate cancer cell metastasis in a mouse xenograft model.
It is demonstrated that YK-4-279 decreases tumor growth and inhibits metastasis in fusion-positive prostate cancer cell xenografts and may have an impact on preventing metastases in prostate cancer patients, which is a leading cause of death.
Abstract 2949: YK-4-279 is a small molecule inhibitor of ETV1 and inhibits metastasis in a mouse model
It is demonstrated that YK-4-279 is a potent inhibitor of ETV1 and should be further evaluated for its clinical applications in prostate cancer.