Sarah J Schmidtke

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In this study we provide, for the first time, experimental evidence that a protein homologous to bacterial Ffh is part of an SRP-like ribonucleoprotein complex in hyperthermophilic archaea. The gene encoding the Ffh homologue in the hyperthermophilic archaeote Acidianus ambivalens has been cloned and sequenced. Recombinant Ffh protein was expressed in E.(More)
Two adjacent genes of the acidophilic and hyperthermophilic crenarchaeon Acidianus ambivalens were cloned and sequenced. The 1.6 kb genomic nucleotide sequence under investigation consists of the 1.12 kb SRa gene encoding the putative signal recognition particle receptor alpha subunit (SR alpha, 42.2 kDa) and the 186 basepair secE gene coding for the(More)
The local environment dictates the structural and functional properties of many important chemical and biological systems. The impact of pH on the photophysical properties of a series of para-aminobenzoic acids is examined using a combination of experimental spectroscopy and quantum chemical calculations. Following photoexcitation, PABA derivatives may(More)
Thermoreversible gelation of rodlike poly(γ-stearyl-R-L-glutamate) in n-dodecane has been studied by differential scanning calorimetry, polarized light microscopy, visual observations, and temperature ramped fluorescence photobleaching recovery. Solutions spanning a wide range of concentrations can produce gels. In solutions that are initially liquid(More)
The dynamics of a series of 1-acylaminoanthraquinones with varying degrees of excited-state intramolecular proton transfer are studied in acetonitrile and dichloromethane. Events are followed via changes in the third-order intermolecular Raman response as a function of time after resonant excitation of the chromophore. Compared to electronically resonant(More)
The effect a solvent has on the photophysical properties of a series of benzophenone derivatives, all FDA approved for use in sunscreens, is examined. Experimentally significant differences in the solvatochromic behavior are found to be dependent upon the substituents on the parent benzophenone molecule. The spectral trends do not appear to originate from(More)
A 1.64 kb genomic DNA sequence from the hyperthermophilic crenarchaeon Sulfolobus acidocaldarius is composed of two adjacent genes. The first functionally unassigned open reading frame (orf-1) comprises 450 base pairs. The second 1.1 kb large open reading frame encodes the putative signal recognition particle receptor alpha subunit (SR alpha). Both genes(More)
The synthesis, structure, and properties of six luminescent pyridylpyrrolide complexes and the first structural characterization of pyridylpyrrolide metal complexes are reported. A series of new zinc complexes, bis(pyridylpyrrolyl)zinc, (R2PyrPy)2Zn (R = Me, Et, iPr, tBu, and Ph), that vary in their substituents on the pyrrole ring (Me, Et, iPr, tBu, and(More)
Excited state intramolecular proton transfer in 1-chloroacetylaminoanthraquinone is investigated from the perspective of the solvent. Using a new two-dimensional nonlinear optical spectroscopy the solvent response is probed directly as the proton transfer takes place. The measurements indicate that solvent reorganization controls the proton transfer in(More)
A 1.6 kb genomic DNA fragment derived from the extremely thermoacidophilic archaeon Sulfolobus acidocaldarius (DSM 639) comprises four open reading frames. The sequence contains three genes encoding crenarchaeal ribosomal proteins with apparent molecular masses of 6.3 kDa, 15.2 kDa and 9.9 kDa, which all represent strongly basic properties. These were(More)
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