Sarah J Janssen

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OBJECTIVE To evaluate the possible role of endocrine-disrupting compounds (EDCs) on female reproductive disorders emphasizing developmental plasticity and the complexity of endocrine-dependent ontogeny of reproductive organs. Declining conception rates and the high incidence of female reproductive disruptions warrant evaluation of the impact of EDCs on(More)
STUDY QUESTION Is first trimester phthalate exposure associated with anogenital distance (AGD), a biomarker of prenatal androgen exposure, in newborns? SUMMARY ANSWER Concentrations of diethylhexyl phthalate (DEHP) metabolites in first trimester maternal urine samples are inversely associated with AGD in male, but not female, newborns. WHAT IS KNOWN(More)
OBJECTIVE Environmental chemicals are widely found in food and personal care products and may have adverse effects on fetal development. Our aim was to examine women's attitudes about these chemicals and ask whether they try to limit their exposure during pregnancy. STUDY DESIGN A multi-center cohort of women in the first trimester of pregnancy completed(More)
THE OIL SPILL IN THE GULF OF MEXICO POSES DIRECT threats to human health from inhalation or dermal contact with the oil and dispersant chemicals, and indirect threats to seafood safety and mental health. Physicians should be familiar with health effects from oil spills to appropriately advise, diagnose, and treat patients who live and work along the Gulf(More)
BACKGROUND Assessing adverse effects from environmental chemical exposure is integral to public health policies. Toxicology assays identifying early biological changes from chemical exposure are increasing our ability to evaluate links between early biological disturbances and subsequent overt downstream effects. A workshop was held to consider how the(More)
Phthalates are ubiquitous endocrine-disrupting chemicals that are contaminants in food and contribute to significant dietary exposures. We examined associations between reported consumption of specific foods and beverages and first trimester urinary phthalate metabolite concentrations in 656 pregnant women within a multicenter cohort study, The Infant(More)
INTRODUCTION There are increasing concerns over the presence and implications of pharmaceutical agents in water. In 2002, California banned pharmaceutical use of lindane because of concerns about water quality, as lindane treatment for head lice and scabies was found to be a significant factor adversely affecting wastewater quality. OBJECTIVES In this(More)
BACKGROUND Current approaches to chemical screening, prioritization, and assessment are being reenvisioned, driven by innovations in chemical safety testing, new chemical regulations, and demand for information on human and environmental impacts of chemicals. To conceptualize these changes through the lens of a prevalent disease, the Breast Cancer and(More)
The presence of pharmaceuticals in our waterways and drinking water is a serious problem that has gained national attention with the public, lawmakers, and regulators. Identifying effective and efficient solutions is hampered by the complexity of the problemsmultiple sources contribute, only some of which are regulated, often by multiple federal agencies(More)