Sarah J Forster

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PURPOSE The study tested whether nutritional support of older patients during acute illness leads to a clinical benefit. METHODS In this randomized, double-blind, placebo-controlled study, we randomly assigned 445 hospitalized patients aged 65 to 92 years to receive either a normal hospital diet plus 400 mL oral nutritional supplements (223 subjects) or a(More)
Using an immunoperoxidase procedure, we have examined the distribution of laminin and fibronectin in normal human large intestinal mucosa and in 50 cases of rectal adenocarcinoma for which extensive clinical follow up was available. In normal tissue, laminin staining was largely restricted to basement membranes, including that underlying the epithelial(More)
Well-defined basement membrane laminin was seen in 98/158 (62%) rectal adenocarcinomas stained by an immunoperoxidase method. Only 27 (28%) patients with laminin-positive tumours developed distant metastases, compared with 39 (65%) patients with laminin-negative carcinomas. The corrected 5-year survival rates for patients with laminin-positive and(More)
OBJECTIVE We measured the effects of acute-phase response on nutritional status and clinical outcome in hospitalized older patients. METHODS Four hundred forty-five patients who took part in a randomized, double-blind, placebo-controlled trial of nutritional supplementation had their nutritional status assessed from anthropometric, hematologic, and(More)
BACKGROUND Although smokers have poor health and consequently poor dietary intake compared with nonsmokers, no study has examined the effects of smoking on nutrition status during acute illness. The purpose of this study is to measure the effect of smoking on nutrition status in hospitalized patients. DESIGN Four hundred and thirty-four patients in a(More)
BACKGROUND Undenutrition is known to be prevalent and largely unrecognised in older patients; however, aberrations in indicators of nutritional status may simply reflect effects of age and/or functional disability. OBJECTIVE The aim of this study was to measure the effect, if any of age on nutritional status in older patients. DESIGN 445 randomly(More)
BACKGROUND & AIMS Undernutrition in hospitalised patients is likely to be contributed to by the dual action of the underlying disease and acute catabolism associated with it. The aim of this study was to measure the association between underlying disease and nutritional status in acutely ill older patients. METHODS Four hundred and forty-five randomly(More)
BACKGROUND & AIMS The effect of nutritional supplements on mental health in older patients has received little attention so far. The aims of this trial were therefore to test the effect of nutritional support on older patient's depressive symptoms and cognitive function. METHODS In this prospective, double-blind, placebo-controlled study, we randomly(More)
OBJECTIVES To test the effect of nutritional support on older patient's quality of life. DESIGN Double-blind, randomized, placebo-controlled trial conducted from March 2001 to January 2004. SETTING United Kingdom. PARTICIPANTS Two hundred twenty-five hospitalized acutely ill older patients. INTERVENTION Normal hospital diet plus 400-mL oral(More)