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An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage.
A compelling genetic association with osteoarthritis (OA) of a functional SNP (rs143383, T/C) in the 5'-UTR of the GDF5 gene was recently reported in case-control cohorts from Japan and China. GDF5Expand
Nursery inoculation of Eucalyptus seedlings in Western Australia and Southern China using spores and mycelial inoculum of diverse ectomycorrhizal fungi from different climatic regions
A large-scale ectomycorrhizal (ECM) fungus inoculation program was conducted in plantation forest tree nurseries in Australia and China over a period of 2 years. These experiments used a wideExpand
A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis
Summary Objective To identify osteoarthritis (OA) relevant genes and pathways in damaged and undamaged cartilage isolated from the knees of patients with anteromedial gonarthrosis (AMG) – a specificExpand
Identifying the optimum source of mesenchymal stem cells for use in knee surgery
Single sitting procedures where the mononuclear cell fraction is extracted from bone marrow and implanted directly into cartilage and bone defects are becoming more popular as novel treatments forExpand
Increasing age and tear size reduce rotator cuff repair healing rate at 1 year
Background and purpose — There is a need to understand the reasons why a high proportion of rotator cuff repairs fail to heal. Using data from a large randomized clinical trial, we evaluated age andExpand
Differences in glutamate receptors and inflammatory cell numbers are associated with the resolution of pain in human rotator cuff tendinopathy
IntroductionThe relationship between peripheral tissue characteristics and pain symptoms in soft tissue inflammation is poorly understood. The primary aim of this study was to determineExpand
Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype
Purpose Osteoarthritis (OA) is a common and heterogeneous arthritic disorder. Patients suffer pain and their joints are characterized by articular cartilage loss and osteophyte formation. RiskExpand
H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis
BackgroundEpigenetic changes (i.e., chromatin modifications) occur during chondrogenesis and in osteoarthritis (OA). We investigated the effect of H3K27me3 demethylase inhibition on chondrogenesisExpand
Augmenting endogenous repair of soft tissues with nanofibre scaffolds
We discuss the types of biomaterial scaffolds available before exploring physical, chemical and biological modifications to synthetic scaffolds. Expand
Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus.
OBJECTIVE A genetic association with knee osteoarthritis (OA) of a single nucleotide polymorphism (SNP) in intron 1 of the LRCH1 gene was recently reported in a UK Caucasian case-control sample andExpand