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In the current experiment we conducted a multi-level analysis of age-related characteristics in the hippocampus of young adult (3 months), middle-aged (12 months), and old (24 months) Fisher 344xBrown Norway hybrid (FBNF1) rats. We examined the relationships between aging, hippocampus, and memory using a combination of behavioral, non-invasive magnetic(More)
• acts as an international forum for the discussion of HCI issues • fosters communication between academic researchers and practitioners • encourages the flow of information across the boundaries of its contributing disciplines • stimulates ideas and provokes widespread discussion with a forward-looking perspective Topics covered include: • systems and(More)
Consistent with configural/conjunctive theories of the hippocampus, we report that rats trained on the non-linear transverse patterning discrimination problem (A+ versus B-, B+ versus C-, and C+ versus A) displayed retrograde amnesia when the hippocampus was later damaged. They also failed to relearn the solution to this problem. Damage to the hippocampus(More)
This paper addresses the issues related to improving the overall quality of the requirements tracing process for Independent Verification and Validation analysts. The contribution of the paper is threefold: we define requirements for a tracing tool based on analyst responsibilities in the tracing process; we introduce several new measures for validating(More)
The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague. Comparison at the genomic level is a key step in our understanding of the genetic basis for this pathogenicity spectrum. Here we report the genome of Y. enterocolitica strain 8081 (serotype 0:8;(More)
We have shown previously that the lipophilic photoreagent 3-(trifluoromethyl)3-m-([125I]iodophenyl)-diazirine ([125I]TID) photolabels all four subunits of the Torpedo nicotinic acetylcholine receptor (AChR) and that greater than 70% of this photoincorporation is inhibited by cholinergic agonists and some noncompetitive antagonists, including(More)
It has been established that neurosteroids can either inhibit or enhance GABA(A) receptor activity. Although GABA is the main inhibitory neurotransmitter in the mammalian retina, the effects of neurosteroids on retinal GABAergic activity have not been investigated. The aim of this work was to study the neurochemical and electroretinographic effects of(More)
Funding for the scoping study and this publication was provided to the Academy under a special grant from the Australian Government through the then Department of Education, Science and Training. The views expressed in this report do not necessarily reflect the views of the Government, its Ministers or DEST's successor Departments. as only the second(More)
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