Sarah Horrigan

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The complete primary structure of a new extracellular protein associated with elastic fiber microfibrils was determined by recombinant DNA techniques. Antiserum to insoluble bovine ocular zonule protein was used to screen a lambda gt11 cDNA expression library constructed from whole chick embryo poly(A)+ RNA. The cDNAs encoding immunoreactive fusion(More)
The cellular protooncogene, c-ski, is expressed in all cells of the developing mouse at low but detectable levels. In situ hybridization and Northern blot analyses reveal that some cells and tissues express this gene at higher levels at certain stages of embryonic and postnatal development. RT-PCR results indicate that alternative splicing of exon 2, known(More)
Clerical and administrative errors are the most common mistakes in blood banking, with errors of sample or patient identification accounting for the majority of mistakes. In an effort to reduce the incidence of human errors, three automated donor-recipient identification systems were developed and were evaluated under clinical conditions. After two years of(More)
Following the emergence of Salmonella Enteritidis as a widespread contaminant of eggs and the role of eggs in the transmission of human salmonellosis, control measures were introduced to curb the spread of infection. Two approaches to Salmonella control are currently used by egg producers in Ireland, because Northern Ireland producers, like those in the(More)
Tropoelastin was examined in bovine lung, aortic and ligament tissues using both organ culture and cell-free translation systems. The bovine tissues synthesized two tropoelastin polypeptides of approximately 70,000 and 68,000 daltons. Two polypeptides were also seen amongst the translation products directed by mRNAs isolated from each of the individual(More)
Aortic cells were isolated from 9- and 12-day embryonic chick aortas and cultured for varying periods after first passage. Cells obtained from 9-day tissue remained indefinitely as monolayers and possessed a relatively low rate of tropoelastin synthesis. Cells obtained from 12-day tissue remained monolayers for 4 to 8 days, after which time portions of the(More)
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