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OBJECTIVE To investigate the effects of letrozole in patients undergoing superovulation with gonadotropins and IUI. DESIGN Retrospective analysis. SETTING Academic teaching hospital. PATIENT(S) Women younger than 40 years of age with patent fallopian tubes and infertility of more than 1 year in duration who were undergoing IUI and gonadotropin(More)
AQP3 (aquaporin-3), known as an integral membrane channel in epidermal keratinocytes, facilitates water and glycerol movement into and out of the skin. Here, we demonstrate that AQP3 is also expressed in cultured human skin fibroblasts, which under normal wound healing processes migrate from surrounding tissues to close the wound. EGF (epidermal growth(More)
Trichostatin A (TSA), a hydroxamate-type inhibitor of mammalian histone deacetylases, is emerging as one of a potentially new class of anticancer agents. TSA is known to act by promoting the acetylation of histones, leading to uncoiling of chromatin and activation of a variety of genes implicated in the regulation of cell survival, proliferation,(More)
Ultraviolet radiation-induced cataract has been believed to be associated with degradation of cellular components. We report that, in cultured human lens epithelial cells, UV radiation analogous to H2O2 treatment down-regulates desmosomal protein desmoglein-2. UV radiation induces generation of reactive oxygen species and transiently activates epidermal(More)
The molecular and cellular mechanism of the development of pancreatic cancer is under constant and intensive study, and yet the cure is still out of reach. While surgical treatment is optional, conventional chemotherapy or chemo-radiotherapy remains the best choice. Among others, paclitaxel is proven to be a popular and, to a certain extent, effective(More)
OBJECTIVE To evaluate the effectiveness of administering misoprostol prior to hysteroscopy in achieving cervical dilatation and reducing complications including cervical laceration. DATA SOURCES Computerized searches of MEDLINE, PubMed and EMBASE were conducted using the key words "hysteroscopy" and "misoprostol." References from identified publications(More)
Ultraviolet radiation (UV) induces cell damages leading to skin photoaging and skin cancer. ATP-sensitive potassium (K(ATP)) channel openers (KCOs) have been shown to exert significant myocardial preservation and neuroprotection in vitro and in vivo, and yet the potential role of those KCOs in protection against UV-induced skin cell damage is unknown. We(More)
Ovarian cancer remains the leading cause of fatality among all gynecologic cancers, although promising therapies are in the making. It has been speculated that metastasis is critical for ovarian cancer, and yet the molecular mechanisms of metastasis in ovarian cancer are poorly understood. Growth factors have been proven to play important roles in cell(More)
Inaccuracies in eyewitness accounts can occur when witnesses are exposed to post-event misinformation via discussion with a co-witness. The current study examined the role of co-witness relationship by comparing the memory performance of pairs of romantic couples, friends and previously unacquainted strangers with that of individuals. Ninety-six(More)
STUDY OBJECTIVE To evaluate the effect of uterine artery embolization (UAE) and hysterectomy on ovarian function. DESIGN Prospective case control study (Canadian Task Force classification II-2). SETTING University teaching hospital. PATIENTS Eighty-four healthy premenopausal women with symptomatic uterine myoma(s) undergoing UAE or hysterectomy. (More)