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Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
Candida albicans is the most common cause of serious fungal disease in humans. Creation of isogenic null mutants of this diploid organism, which requires sequential gene targeting, allows dissection… Expand
An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.
- Changbin Chen, K. Pande, Sarah French, B. B. Tuch, S. Noble
- Biology, Medicine
- Cell host & microbe
- 18 August 2011
The mammalian gastrointestinal tract and bloodstream are highly disparate biological niches that differ in concentrations of nutrients such as iron. However, some commensal-pathogenic microorganisms,… Expand
A mutation in the small heat-shock protein HSPB1 leading to distal hereditary motor neuronopathy disrupts neurofilament assembly and the axonal transport of specific cellular cargoes.
- S. Ackerley, P. James, Arran Kalli, Sarah French, K. Davies, K. Talbot
- Medicine, Biology
- Human molecular genetics
- 15 January 2006
Distal hereditary motor neuronopathies (dHMNs) are a clinically and genetically heterogeneous group of disorders in which motor neurons selectively undergo age-dependant degeneration. Mutations in… Expand