Sarah E M Jenkin

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In response to varying environmental and physiological challenges, vertebrates have evolved complex and often overlapping systems. These systems detect changes in environmental oxygen availability and respond by increasing oxygen supply to the tissues and/or by decreasing oxygen demand at the cellular level. This suite of responses is termed the oxygen(More)
The evolution of the aspiration pump seen in tetrapod vertebrates from the buccal-pharyngeal force pump seen in air breathing fish and amphibians appears to have first involved the production of active expiration. Active inspiration arose later. This appears to have involved reconfiguration of a parafacial oscillator (now the parafacial respiratory(More)
Coordination of respiratory pump and valve muscle activity is essential for normal breathing. A hallmark respiratory responses to hypercapnia and hypoxia is the emergence of active exhalation, characterized by abdominal muscle pumping during the late one-third of expiration (late-E phase). Late-E abdominal activity during hypercapnia has been attributed to(More)
While the transition from the inspiratory to the post-inspiratory (post-I) phase is dependent on the pons, little attention has been paid to understanding the role of the pontine respiratory nuclei, specifically the Kölliker-Fuse nucleus (KF), in transitioning from post-I to the late expiratory (late-E) activity seen with elevated respiratory drive. To(More)
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