Sarah E. Hochman

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BACKGROUND The morbidity and mortality associated with malaria are heightened because of the spread of drug-resistant parasites and the lack of an effective vaccine. Plasmodium liver stages are the targets of new chemotherapeutics and vaccines, but there are limited tools available to study this stage in vivo. METHODS To overcome this obstacle, we(More)
HIV and malaria have similar global distributions. Annually, 500 million are infected and 1 million die because of malaria. 33 million have HIV and 2 million die from it each year. Minor effects of one infection on the disease course or outcome for the other would significantly impact public health because of the sheer number of people at risk for(More)
Cerebral malaria (CM) is a major contributor to malaria deaths, but its pathophysiology is not well understood. While sequestration of parasitized erythrocytes is thought to be critical, the roles of inflammation and coagulation are controversial. In a large series of Malawian children hospitalized with CM, HIV coinfection was more prevalent than in(More)
HIV infection is widespread throughout the world and is especially prevalent in sub-Saharan Africa and Asia. Similarly, Plasmodium falciparum, the most common cause of severe malaria, affects large areas of sub-Saharan Africa, the Indian subcontinent, and Southeast Asia. Although initial studies suggested that HIV and malaria had independent impact upon(More)
Sarah E. Hochman,a Theresa F. Madaline,a,b Samuel C. Wassmer,c,d Emmie Mbale,e,f Namjong Choi,g Karl B. Seydel,h,i Richard O. Whitten,j Julie Varughese,a,b Georges E. R. Grau,d Steve Kamiza,k Malcolm E. Molyneux,f,l Terrie E. Taylor,h,i Sunhee Lee,g Danny A. Milner, Jr.,m,n Kami Kima,g,o Department of Medicine, Albert Einstein College of Medicine, Bronx,(More)
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