Sarah E. Hart

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Using a novel algorithm for protein sequence/structure analysis, we propose a probable homology between the SWIB domain (the conserved domain of the 60 kda subunit of the SWIB complex involved in chromatin remodelling) and the p53-binding domain of the MDM2 oncoprotein. The homology suggests that the SWIB domain would adopt a structure similar to that of(More)
BACKGROUND Smith-Lemli-Opitz syndrome (SLOS) is an inborn error of cholesterol biosynthesis characterized by diminished cholesterol and increased 7-dehydrocholesterol (7-DHC) levels. 7-Dehydrocholesterol is highly reactive, giving rise to biologically active oxysterols. METHODS 7-DHC-derived oxysterols were measured in fibroblasts from SLOS patients and(More)
  • bullet Biggs, Carter, +21 authors Fidler
  • 2015
Our scholars accrue strong publication records throughout our program. Below are examples of the peer-reviewed journal publications of our students while they were in our press). Quality of life for transition-age youth with autism or intellectual disability. Journal of Autism and Developmental Disorders. (in press). Family-school partnerships(More)
The interactions between redox proteins are transient in nature. Therefore, very few crystal structures are available for the complexes formed between these proteins. Computational docking simulations thus provide a useful alternative method for studying the interactions between electron transfer proteins. In this paper, we have studied the interactions(More)
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