Sarah Durston

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Adam R. Aron,1 Sarah Durston,6 Dawn M. Eagle,3 Gordon D. Logan,2 Cathy M. Stinear,5 and Veit Stuphorn4 1Department of Psychology, University of California, San Diego, La Jolla, California 92093, 2Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203, 3Department of Experimental Psychology, University of Cambridge, Downing Site,(More)
BACKGROUND Cognitive control, defined as the ability to suppress inappropriate thoughts and actions, is compromised in attention-deficit/hyperactivity disorder (ADHD). This study examines the neural basis of this deficit. METHODS We used a paradigm that incorporates a parametric manipulation within a go/nogo task, so that the number of go trials preceding(More)
The present study explores the neural basis of the development of inhibitory control by combining functional neuroimaging with a parametric manipulation of a go-nogo paradigm. We demonstrate how the maturation of ventral fronto-striatal circuitry underlies the development of this ability. We used event-related fMRI to examine the effect of interference on(More)
The human brain undergoes significant changes in both its structural architecture and functional organization across the life span. Advances in neuroimaging techniques over the past decade have allowed us to track these changes safely in the human in vivo. We review the imaging literature on the neurobiology of cognitive development, focusing specifically(More)
In this study we combined event-related fMRI with a parametric manipulation of the go nogo paradigm to examine the effect of preceding context on inhibitory processes. Nogo trials were preceded by either 1, 3, or 5 go trials and then compared to one another. Two distinct patterns of activation were associated with behavioral inhibition: First, the ventral(More)
Recent imaging studies have suggested that developmental changes may parallel aspects of adult learning in cortical activation becoming less diffuse and more focal over time. However, while adult learning studies examine changes within subjects, developmental findings have been based on cross-sectional samples and even comparisons across studies. Here, we(More)
  • Sarah Durston
  • Mental retardation and developmental disabilities…
  • 2003
Attention Deficit Hyperactivity Disorder (ADHD) is a common and impairing neuropsychiatric disorder with onset at preschool age. Although a significant amount of progress has been made investigating the neurobiology of this disorder, its precise etiology still remains unclear. Converging evidence from studies of the neuropharmacology, genetics,(More)
In the current study we examined the influence of preceding context on attentional conflict and response competition using a flanker paradigm. Nine healthy right-handed adults participated in a rapid mixed trial event-related functional magnetic resonance imaging (fMRI) study, in which increasing numbers of either compatible or incompatible trials preceded(More)
Prevailing theories of implicit or unaware learning propose a developmental invariance model, with implicit function maturing early in infancy or childhood despite prolonged improvements in explicit or intentional learning and memory systems across childhood. Neuroimaging studies of adult visuomotor sequence learning have associated fronto-striatal brain(More)
Genetic influences on behavior are complex and, as such, the effect of any single gene is likely to be modest. Neuroimaging measures may serve as a biological intermediate phenotype to investigate the effect of genes on human behavior. In particular, it is possible to constrain investigations by prior knowledge of gene characteristics and by including(More)