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  • Sarah Caughlin, Jeffrey D. Hepburn, +4 authors Shawn Narain Whitehead
  • Chemistry, Medicine
  • PloS one
  • 2015 (First Publication: 18 June 2015)
  • The aging brain is often characterized by the presence of multiple comorbidities resulting in synergistic damaging effects in the brain as demonstrated through the interaction of Alzheimer's diseaseContinue Reading
  • Nina Weishaupt, Sarah Caughlin, Ken K.-C. Yeung, Shawn Narain Whitehead
  • Biology, Medicine
  • Front. Neuroanat.
  • 2015 (First Publication: 1 December 2015)
  • GM1 ganglioside plays a role in essential neuronal processes, including differentiation, survival, and signaling. Yet, little is known about GM1 species with different sphingosine bases, such as theContinue Reading
  • Sarah Caughlin, Shikhar Maheshwari, Nina Weishaupt, Ken K-C Yeung, David Floyd Cechetto, Shawn Narain Whitehead
  • Chemistry, Medicine
  • Scientific Reports
  • 2017 (First Publication: 23 November 2017)
  • Alterations in the long chain base of the sphingosine moiety of gangliosides have been shown to play a role in neurodevelopment and neurodegeneration. Indeed, the accumulation of d20:1 sphingosineContinue Reading
  • Sarah Caughlin, Shikhar Maheshwari, +6 authors Shawn Narain Whitehead
  • Biology, Medicine
  • Biochimica et biophysica acta. General subjects
  • 2018 (First Publication: 1 June 2018)
  • BACKGROUND Accumulation of simple gangliosides GM2 and GM3, and gangliosides with longer long-chain bases (d20:1) have been linked to toxicity and the pathogenesis of Alzheimer's disease (AD).Continue Reading
  • Sarah Caughlin, Dae Hee Park, Ken K-C Yeung, David Floyd Cechetto, Shawn Narain Whitehead
  • Biology, Medicine
  • Journal of visualized experiments : JoVE
  • 2017 (First Publication: 23 March 2017)
  • Sample preparation is key for optimal detection and visualization of analytes in Matrix-assisted Laser Desorption/Ionization (MALDI) Imaging Mass Spectrometry (IMS) experiments. Determining theContinue Reading
  • Alice Mary Iliescu, Amanda McIntyre, +4 authors Robert William Teasell
  • Medicine
  • Clinical rehabilitation
  • 2019 (First Publication: 18 October 2019)
  • Objective: To meta-analyze and systematically review the effectiveness of aquatic therapy in improving mobility, balance, and functional independence after stroke. Data Sources: Articles published inContinue Reading