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Repeated low-level exposures to biological agents could occur before or after the remediation of an environmental release. This is especially true for persistent agents such as B. anthracis spores, the causative agent of anthrax. Studies were conducted to examine aerosol methods needed for consistent daily low aerosol concentrations to deliver a low-dose(More)
There is a need to better understand inhalational anthrax in relevant animal models. This understanding could aid risk assessment, help define therapeutic windows, and provide a better understanding of disease. The aim here was to characterize and quantify bacterial deposition and dissemination in rabbits following exposure to single high aerosol dose (>(More)
In the event of an indoor release of an environmentally persistent microbial pathogen such as Bacillus anthracis, the potential for human exposure will be considered when remedial decisions are made. Microbial site characterization and clearance sampling data collected in the field might be used to estimate exposure. However, there are many challenges(More)
ii Disclaimer This document provides internal guidance to U.S. Environmental Protection Agency (EPA) personnel; EPA retains the discretion, however, to adopt, on a case-by-case basis, approaches that differ from this guidance. The guidance set forth in this document does not create any rights, substantive or procedural, enforceable by law for a party in(More)
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