Sarah C.R Elgin

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Recent results from diverse organisms point to a self-reinforcing network of interactions among the three best-characterized covalent modifications that mark heterochromatin: histone hypoacetylation, histone H3-Lys9 methylation, and cytosine methylation. These modification systems suggest a mechanistic basis for spreading of heterochromatin over large(More)
RAP1 and core histones can spread from the telomere at a terminal truncation into adjacent regions (reviewed Department of Biology St. Louis, Missouri 63130 by Grunstein, 1998). One can infer that discrete boundaries are needed to maintain the mosaic pattern of silent and active domains found under normal conditions; indeed , such " barriers " to the spread(More)
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