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Information and Communication Technologies are increasingly intertwined across the economies and societies of developed countries. Protecting these technologies from cyber-threats requires collaborative relationships for exchanging cyber defense data and an ability to establish trusted relationships. The fact that Communication and Information Systems (CIS)(More)
Across the world, organizations have teams gathering threat data to protect themselves from incoming cyber attacks and maintain a strong cyber security posture. Teams are also sharing information, because along with the data collected internally, organizations need external information to have a comprehensive view of the threat landscape. The information(More)
BACKGROUND Previous studies indicate that disulfiram (DS), an anti-alcoholism drug, is cytotoxic to cancer cell lines and reverses anticancer drug resistance. Cancer stem cells (CSCs) are the major cause of chemoresistance leading to the failure of cancer chemotherapy. This study intended to examine the effect of DS on breast cancer stem cells (BCSCs). (More)
The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting side effects and the ability of tumors to develop resistance rapidly. These drugs can be improved through the use of drug-delivery vehicles that are able to target cancers passively or actively. In(More)
BACKGROUND Glioblastoma multiforme (GBM) cells are resistant to anticancer drugs. Cancer stem cells (CSCs) are a key mediator of chemoresistance. We have reported that disulfiram (DS), an aldehyde dehydrogenase (ALDH) inhibitor, targets breast CSC-like cells. In this study, the effect of DS and combination of DS and gemcitabine (dFdC) on GBM cells and GBM(More)
BACKGROUND Triple-negative breast cancer (TNBC) has significantly worse prognosis. Acquired chemoresistance remains the major cause of therapeutic failure of TNBC. In clinic, the relapsed TNBC is commonly pan-resistant to various drugs with completely different resistant mechanisms. Investigation of the mechanisms and development of new drugs to target(More)
The need for more fluent information sharing has been recognized for years as a major requirement by the cyber security community. Information sharing at present is mostly a slow, inefficient, and manual process that in many cases uses non-structured data sources. It is true that several cyber security data sharing tools have emerged and are currently(More)
This paper presents a study that explores the use of mediation in virtual environments (VEs) used for cultural storytelling. A VE was created in which a traditional San story was told. Two forms of mediation were used: visual and audio. Four versions of the VE were implemented, differentiated by the types of mediation included. An experiment was conducted,(More)
Breast cancer stem cells (BCSCs) are pan-resistant to different anticancer agents and responsible for cancer relapse. Disulfiram (DS), an antialcoholism drug, targets CSCs and reverses pan-chemoresistance. The anticancer application of DS is limited by its very short half-life in the bloodstream. This prompted us to develop a liposome-encapsulated DS(More)
Sir, We thank Dr Cvek (2013), this issue, for his interest in our study and providing very important information in his letter. In order to apply disufiram (DS) in cancer treatment, we would address the following issues. Our studies suggest that copper is essential for anticancer activity of DS in vitro (Yip et al, 2011; Liu et al, 2012) and in vivo(More)