The Evolution of Gene Expression in cis and trans.
- Sarah A. Signor, S. Nuzhdin
- BiologyTrends in Genetics
- 1 July 2018
A Large Panel of Drosophila simulans Reveals an Abundance of Common Variants
- Sarah A. Signor, Felicia N New, S. Nuzhdin
- BiologyGenome Biology and Evolution
- 8 December 2017
A new panel of 170 inbred genotypes of a North American population of D. simulans is sequence, a valuable complement to the DGRP and other D. melanogaster panels, to attempt to parse the contribution of demography and selection to the patterns observed in this population.
Population genomics of Wolbachia and mtDNA in Drosophila simulans from California
- Sarah A. Signor
- 11 August 2017
A phylogeny of Wolbachia and of mtDNA suggest a recent origin of the infection derived from a single origin, and the first association analysis using this phenotype with the nuclear genome is performed, finding several implicated regions, including one which contains four CAAX-box protein processing genes.
Genetic Convergence in the Evolution of Male-Specific Color Patterns in Drosophila
- Sarah A. Signor, Yang Liu, M. Rebeiz, A. Kopp
- BiologyCurrent Biology
- 26 September 2016
Social effects for locomotion vary between environments in Drosophila melanogaster females
- Sarah A. Signor, M. Abbasi, P. Marjoram, S. Nuzhdin
- BiologyEvolution; international journal of organic…
- 1 July 2017
It is concluded that IGEs are an important component of social and sexual interactions and that they vary between individuals and abiotic environments in complex ways, with the potential to promote the maintenance of phenotypic variation.
Evolutionary dynamics of piRNA clusters in Drosophila
- Filip Wierzbicki, R. Kofler, Sarah A. Signor
- 20 August 2021
It is shown that piRNA clusters are evolving rapidly, and the evolution of clusters is mainly driven by large insertions of recently active TEs, and smaller deletions mostly in older TEs.
Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster
- Sarah A. Signor, S. Nuzhdin
- 24 August 2018
It is found that while D. melanogaster responds to ethanol, there is very little genetic variation in how it responds toanol, suggesting that incorporating time into studies on the response to the environment is important.
Genetic Basis of a Violation of Dollo’s Law: Re-Evolution of Rotating Sex Combs in Drosophila bipectinata
- Thaddeus D Seher, C. Ng, Sarah A. Signor, O. Podlaha, O. Barmina, A. Kopp
- 1 December 2012
The genetic architecture of the Drosophila sex comb suggests that rotating sex combs may have re-evolved through changes in relatively few genes, and potential developmental mechanisms that may allow lost complex structures to be regained are discussed.
Genomic resources for multiple species in the Drosophila ananassae species group
- Sarah A. Signor, Thaddeus D Seher, A. Kopp
- 1 January 2013
The ananassae subgroup is an excellent model system for examining the molecular basis of speciation and phenotypic evolution and new genomic resources will facilitate the genetic analysis of inter- and intraspecific differences in this lineage.
Novel approach to quantitative spatial gene expression uncovers genetic stochasticity in the developing Drosophila eye
- S. Ali, Sarah A. Signor, K. Kozlov, S. Nuzhdin
- BiologyEvolution & Development
- 12 February 2019
There is considerable variation in the spatial expression pattern of these genes in the eye between species, genotypes, and sexes, and there has been evolution of the regulatory relationship between these genes, and their spatial interrelationships have evolved between species.