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NBR1 acts as an autophagy receptor for peroxisomes.

• Elizabeth Deosaran, Kenneth Bowitz Larsen, +10 authors Peter Kijun Kim
• Journal of cell science
• 2013

Selective macro-autophagy is an intracellular process by which large cytoplasmic materials are selectively sequestered and degraded in the lysosomes. Substrate selection is mediated by ubiquitylation… (More)

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

• Ronald J. Buckanovich, Andrea Facciabene, +7 authors George Coukos
• Nature Medicine
• 2008

In spite of their having sufficient immunogenicity, tumor vaccines remain largely ineffective. The mechanisms underlying this lack of efficacy are still unclear. Here we report a previously… (More)

Response of experimental retinal neovascularization to thiazolidinediones.

• Toshinori Murata, Yasuaki Hata, +4 authors David R Hinton
• Archives of ophthalmology
• 2001

OBJECTIVE To determine the effect of thiazolidinediones (TZDs) on experimental retinal neovascularization. METHODS The ability of the TZDs troglitazone and rosiglitazone maleate (1-20 micromol/L)… (More)

Osteopontin modulates angiotensin II-induced fibrosis in the intact murine heart.

• Alan R. Collins, Janet Schnee, +7 authors Willa A. Hsueh
• Journal of the American College of Cardiology
• 2004

OBJECTIVES Osteopontin (OPN) is upregulated in left ventricular hypertrophy and is stimulated by angiotensin II (AngII). Our objective was to determine whether mice deficient in OPN would be… (More)

Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.

• Andrea Ablasser, Hendrik Poeck, +11 authors V. Hornung
• Journal of immunology
• 2009

Detection of non-self RNA by TLRs within endosomes and by retinoic acid-inducible gene I (RIG-I)-like helicases in the cytosol is central to mammalian antiviral immunity. In this study, we used… (More)

Transcriptional Regulation of PIK3CA Oncogene by NF-κB in Ovarian Cancer Microenvironment

• Nuo Yang, Jia Huang, +10 authors George Coukos
• PloS one
• 2008

PIK3CA upregulation, amplification and mutation have been widely reported in ovarian cancers and other tumors, which strongly suggests that PIK3CA is a promising therapeutic target. However, to date… (More)

Effect of endothelin-1 (1-31) on extracellular signal-regulated kinase and proliferation of human coronary artery smooth muscle cells.

• Masanori Yoshizumi, Sarah A Kim, +6 authors Toshiaki Tamaki
• British journal of pharmacology
• 1998

1. We have previously found that human chymase cleaves big endothelins (ETs) at the Tyr31-Gly32 bond and produces 31-amino acid ETs (1-31), without any further degradation products. In this study, we… (More)

<ce:italic>In</ce:italic><ce:italic>vitro</ce:italic> application of gold nanoprobes in live neurons for phenotypical classification, connectivity assessment, and electrophysiological recording

• Karl C. Mendoza, Virginia D. McLane, Sarah A Kim, John D. Griffin
• Brain Research
• 2010

Thermoregulatory neurons in the preoptic area of the anterior hypothalamus (POA) form synaptic networks, which affect responses that regulate body temperature. To characterize these pathways of… (More)

Direct crosstalk between cancer and osteoblast lineage cells fuels metastatic growth in bone via auto-amplification of IL-6 and RANKL signaling pathways.

• Yu Zheng, Shu-Oi Chow, +10 authors Markus J. Seibel
• Journal of bone and mineral research : the…
• 2014

The bone microenvironment and its modification by cancer and host cell interactions is a key driver of skeletal metastatic growth. Interleukin-6 (IL-6) stimulates receptor activator of NF-κB ligand… (More)

Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation.

• Hyeongju Ryu, Julia K. L. Walker, +5 authors Kwang-Mahn Kim
• British journal of pharmacology
• 2008

BACKGROUND AND PURPOSE M2-type pyruvate kinase (M2PK) was found to interact directly with the 'ITAM' region of the gamma chain of the high-affinity IgE receptor (FcvarepsilonRI). Our hypothesis was… (More)

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