Sarah A. Jones

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The archaeal/eukaryotic proliferating cell nuclear antigen (PCNA) toroidal clamp interacts with a host of DNA modifying enzymes, providing a stable anchorage and enhancing their respective processivities. Given the broad range of enzymes with which PCNA has been shown to interact, relatively little is known about the mode of assembly of functionally(More)
This study has investigated the possibility that acetylcholinesterase could play a non-classical role as an adhesion factor or growth factor in the development of dopaminergic neurons in organotypic slice culture of postnatal day 1 rats. When the culture medium was supplemented with acetylcholinesterase (3 U/ml), outgrowth of tyrosine(More)
Retinoic acid (RA), a vitamin A metabolite, modulates mucosal T helper cell responses. Here we examined the role of RA in regulating IL-22 production by γδ T cells and innate lymphoid cells in intestinal inflammation. RA significantly enhanced IL-22 production by γδ T cells stimulated in vitro with IL-1β or IL-18 and IL-23. In vivo RA attenuated colon(More)
BACKGROUND There are many reports on the complications that occur at the time of insertion and during the life of central venous indwelling catheters. However, there is no literature that describes the complications that occur at the time of removal of these lines. METHODS A retrospective review of 136 central line (Broviacs [B], Port-A- Caths [PC] and(More)
Corticotropin-releasing hormone is produced by the human placenta and fetal membranes, but its physiological significance is not established. We examined the possibility that CRH might affect prostaglandin output by these intra-uterine tissues. Primary cultures of amnion, chorion, decidua and placenta were established from tissue obtained from women at term(More)
BACKGROUND There have been many reports of complications of central venous lines in children but limited discussion of the specific problem of retained intravascular fragments after attempted removal. We report on a series of 6 patients from 2 tertiary pediatric hospitals that had intravascular segments of long-term central venous lines that could not be(More)
Thirty individuals with Bipolar I Disorder (16 individuals had relapsed within the last 2 years; 14 individuals had remained well over this period) were hypothesized to score higher on extreme positive and negative appraisals of internal state (HAPPI; Hypomanic Attitudes and Positive Predictions Inventory) than three control groups: remitted unipolar(More)
OBJECTIVES This study explored the process of recovery from bipolar I disorder from a phenomenological and cognitive perspective. DESIGN A semi-structured interview was coded and analysed using interpretative phenomenological analysis. METHODS Eleven individuals over the age of 30 with a history of bipolar disorder were selected on the basis of having(More)
Elevated concentrations of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) in the synovial fluids and serum of patients with arthritis have been implicated in the joint tissue destruction associated with these conditions, however studies conducted to date on the role and effects of IL-6 in the process of cartilage proteoglycan (aggrecan) catabolism(More)