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Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5-10% of the cases are familial ALS. Both sporadic and familial ALS (FALS) are associated with degeneration of cortical and spinal motor neurons. The etiology of ALS remains… (More)
Cystic fibrosis (CF) is the most common autosomal recessive disease in Caucasians with a reported incidence of 1 in every 3200 live births. Most strikingly, CF is associated with early mortality. Host in flammatory responses result in airway mucus plugging, airway wall edema, and eventual destruction of airway wall support structure. Despite aggressive… (More)
Cystic fibrosis (CF) is a chronic progressive pulmonary disorder caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene. A CF lung is generally characterized by obstructed airflow to an extent that leads to destruction of airway wall support structure. Airway resistance, resulting from both laminar and turbulent flow, is… (More)
Cystic fibrosis is an inherited chronic disease that affects the lungs, digestive system and even circulatory system of CF patients. Understanding the CF patient's lung and airway as an ecosystem is a novel and powerful point of view. There are many different microbes in CF lungs that no one has ever cultured and the chronically colonized CF airways… (More)
—In this research, we applied both supervised and un-supervised machine learning methodologies to spirometric data from patients with cystic fibrosis (CF). We developed an ensemble of neural networks to evaluate the severity of chronic CF within an individual, given the appropriate clinical input data, and a series of reference equations to describe the CF… (More)
"Modeling the airflow in a lung with cystic fibrosis,"
Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) scan are the two ubiquitous imaging sources that physicians use to diagnose patients with Cystic Fibrosis (CF) or any other Chronic Obstructive Pulmonary Disease (COPD). Unfortunately the cost constraints limit the frequent usage of these medical imaging procedures. In addition, even though both… (More)