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Studies of protein N-glycosylation are important for answering fundamental questions on the diverse functions of glycoproteins in plant growth and development. Here we generated and characterised a comprehensive collection of Lotus japonicusLORE1 insertion mutants, each lacking the activity of one of the 12 enzymes required for normal N-glycan maturation in(More)
BACKGROUND/OBJECTIVES Anaphylaxis due to hymenoptera stings is one of the most severe clinical outcomes of IgE-mediated hypersensitivity reactions. Although allergic reactions to hymenoptera stings are often considered as a general model for the underlying principles of allergic disease, venom immunotherapy is still hampered by severe systemic side effects(More)
O1 Two cell‐membrane peptidases carrying galactose‐alpha‐1,3‐galactose are implicated in delayed anaphylactic reactions upon pork kidney ingestion in patients with IgE‐antibodies to alpha‐Gal Christiane Hilger, Kyra Swiontek, Jörg Fischer, François Hentges, Chris‐ tiane Lehners, Martine Morisset, Bernadette Eberlein, Tilo Biedermann, Markus Ollert(More)
TH2-biased immunity to parasites and allergens is often associated with increased levels of antigen-specific and high affinity IgE. The role in reacting against minute amounts of target structures and to provoke severe anaphylactic reactions renders IgE a mechanistically outstanding isotype. IgE represents the least abundant serum antibody isotype and(More)
Allergen-specific immunotherapy is the only curative treatment of honeybee venom (HBV) allergy, which is able to protect against further anaphylactic sting reactions. Recent analyses on a molecular level have demonstrated that HBV represents a complex allergen source that contains more relevant major allergens than formerly anticipated. Moreover, allergic(More)
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