Sara Vandenwijngaert

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BACKGROUND Ventricular expression of phosphodiesterase-5 (PDE5), an enzyme responsible for cGMP catabolism, is increased in human right ventricular hypertrophy, but its role in left ventricular (LV) failure remains incompletely understood. We therefore measured LV PDE5 expression in patients with advanced systolic heart failure and characterized LV(More)
Numerous common genetic variants have been linked to blood pressure, but no underlying mechanism has been elucidated. Population studies have revealed that the variant rs5068 (A/G) in the 3' untranslated region of NPPA, the gene encoding atrial natriuretic peptide (ANP), is associated with blood pressure. We selected individuals on the basis of rs5068(More)
OBJECTIVES We compared biological repair after acute myocardial infarction (AMI) with selected porcine progenitor cell populations. BACKGROUND Cell types and mechanisms responsible for myocardial repair after AMI remain uncertain. METHODS In a blinded, randomized study, we infused autologous late-outgrowth endothelial progenitor cells (EPC) (n = 10, 34(More)
BACKGROUND Microvascular endothelium in different organs is specialized to fulfill the particular needs of parenchymal cells. However, specific information about heart capillary endothelial cells (ECs) is lacking. METHODS AND RESULTS Using microarray profiling on freshly isolated ECs from heart, brain, and liver, we revealed a genetic signature for(More)
BACKGROUND The intracellular second messenger cGMP protects the heart under pathological conditions. We examined expression of phosphodiesterase 5 (PDE5), an enzyme that hydrolyzes cGMP, in human and mouse hearts subjected to sustained left ventricular (LV) pressure overload. We also determined the role of cardiac myocyte-specific PDE5 expression in adverse(More)
Placental growth factor (PlGF) has a distinct biological phenotype with a predominant proangiogenic role in disease without affecting quiescent vessels in healthy organs. We tested whether systemic administration of recombinant human (rh)PlGF improves regional myocardial blood flow (MBF) and systolic function recovery in a porcine chronic myocardial(More)
AIMS The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity. RESULTS Doxorubicin administration (20 mg/kg, intraperitoneally [IP]) reduced cardiac sGC activity in(More)
Since there is a close relationship between the periodontium and the pulp, formed by the apical foramen, dentinal tubules, lateral and accessory canals, it is evident that both compartments influence one other. In this article, the influence of periodontal disease and its treatment on the dental pulp is described. The review shows that periodontal disease(More)
Background The nitric oxide (NO)-soluble guanylate cyclase (sGC)cyclic guanosine 3’5’-monophosphate (cGMP) pathway regulates intraocular pressure (IOP). Preclinical and clincial studies have demonstrated the ability of NO-donor compounds to lower IOP (e.g. VESNEO). The use of inhaled NO gas (iNO), a specific pulmonary but not systemic vasodilator, is an(More)
Background The use of doxorubicin (DOX), a potent chemotherapeutic agent, is limited by cardiotoxicity, leading to congestive heart failure in up to 5% of DOX-treated patients. Dysfunctional cyclic guanosine 3’, 5’-monophosphate (cGMP) signaling has been implicated in various cardiovascular diseases, including cardiotoxicity associated with DOX(More)