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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission. Expand
Mice lacking the norepinephrine transporter are supersensitive to psychostimulants
In a classical test for antidepressant drugs, the NET-deficient (NET−/−) animals behaved like antidepressant-treated wild-type mice, and were hyper-responsive to locomotor stimulation by cocaine or amphetamine. Expand
The hypocretin–orexin system regulates cocaine self‐administration via actions on the mesolimbic dopamine system
These studies suggest that hypocretin neurotransmission participates in reinforcement processes, likely through modulation of the mesolimbic dopamine system, and suggest that the hypoc retin system may provide a target for pharmacotherapies to treat cocaine addiction. Expand
Demon Voltammetry and Analysis software: Analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures
The Demon Voltammetry and Analysis software suite was used to compare the sensitivity of multiple kinetic measures of release and uptake to cocaine-induced changes in electrically evoked dopamine efflux in nucleus accumbens core slices and recommended tau for measuring dopamine uptake and calibrated peak dopamine concentration forasuring dopamine release. Expand
Knockout of the Vesicular Monoamine Transporter 2 Gene Results in Neonatal Death and Supersensitivity to Cocaine and Amphetamine
These mice may provide an animal model for delineating the mechanisms of vesicular release, monoamine function, and postsynaptic sensitization associated with drug abuse and stress the importance of VMAT2 in the maintenance of presynaptic function. Expand
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
Biased agonists of the kappa opioid receptor may relieve intractable itch without causing unwanted side effects. Itch relief from biased agonists Activating the kappa opioid receptor (KOR) canExpand
Cocaine self-administration in dopamine-transporter knockout mice
On page 134, Fig. 4 was inadvertently printed in black and white instead of color and the corrected version is printed below. Expand
Loss of autoreceptor functions in mice lacking the dopamine transporter
Direct assessment of impulse-, synthesis- and release-regulating autoreceptors in these mice reveals a nearly complete loss of function, which may provide insight into the neurochemical consequences of hyperdopaminergia. Expand
Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis 1 Published on the World Wide Web on 27 January 1998. 1
A crucial role is indicated for the DAT in maintenance of DA neuron presynaptic function, particularly in the control of storage mechanisms. Expand
Functional hyperdopaminergia in dopamine transporter knock-out mice
The mice lacking the dopamine transporter gene may represent an appropriate model to elucidate the molecular adaptive changes accompanying pathological states associated with hyperdopaminergic function. Expand