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Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo.

• Maura Poli, Domenico Girelli, +5 authors Paolo Arosio
• Blood
• 2011

Hepcidin is a major regulator of iron homeostasis, and its expression in liver is regulated by iron, inflammation, and erythropoietic activity with mechanisms that involve bone morphogenetic proteins… (More)

Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent…

• Maura Poli, Sara Luscieti, +5 authors Paolo Arosio
• Haematologica
• 2010

BACKGROUND Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2. However, the role of these proteins… (More)

Pantothenate kinase-2 (Pank2) silencing causes cell growth reduction, cell-specific ferroportin upregulation and iron deregulation

• Maura Poli, Manuela Derosas, Sara Luscieti, Patrizia Cavadini, Paolo Arosio
• Neurobiology of Disease
• 2010

Pantothenate kinase 2 (Pank2) is a mitochondrial enzyme that catalyses the first regulatory step of Coenzyme A synthesis and that is responsible for a genetic movement disorder named Pank-associated… (More)

Siderophore-mediated iron trafficking in humans is regulated by iron

• Zhuoming Liu, Robert Lanford, +4 authors Lax Devireddy
• Journal of Molecular Medicine
• 2012

Siderophores are best known as small iron binding molecules that facilitate microbial iron transport. In our previous study we identified a siderophore-like molecule in mammalian cells and found that… (More)

The actin-binding protein profilin 2 is a novel regulator of iron homeostasis.

• Sara Luscieti, Bruno Galy, +8 authors Mayka Sanchez
• Blood
• 2017

Cellular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis-regulatory iron-responsive elements (IRE) on target messenger RNAs (mRNA). We identified profilin… (More)

Novel mutations in the ferritin-L iron-responsive element that only mildly impair IRP binding cause hereditary hyperferritinaemia cataract syndrome

• Sara Luscieti, Gabriele Tolle, +5 authors Mayka Sanchez
• Orphanet journal of rare diseases
• 2013

BACKGROUND Hereditary Hyperferritinaemia Cataract Syndrome (HHCS) is a rare autosomal dominant disease characterized by increased serum ferritin levels and early onset of bilateral cataract. The… (More)

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