Synthesis of Trifluoromethylated Azetidines, Aminopropanes, 1,3-Oxazinanes, and 1,3-Oxazinan-2-ones Starting from 4-Trifluoromethyl-β-lactam Building Blocks
- Hang Dao Thi, L. Decuyper, M. D’hooghe
- Chemistry
- 20 January 2016
This paper reports on the preparation of 4-(trifluoromethyl)azetidin-2-ones and their synthetic potential as eligible new building blocks for the construction of CF3-containing azetidines,…
Synthesis of 1-alkyl-2-(trifluoromethyl)azetidines and their regiospecific ring opening toward diverse α-(trifluoromethyl)amines via intermediate azetidinium salts.
- Sara Kenis, M. D’hooghe, N. de Kimpe
- ChemistryJournal of Organic Chemistry
- 6 July 2012
The reactivity profile of these 2-CF(3)-azetidines was assessed by means of quaternization and subsequent regiospecific ring opening at C4 of the azetidinium intermediates by oxygen, nitrogen, carbon, sulfur, and halogen nucleophiles, pointing to a clear difference in reactivity compared to azetidsines bearing other types of electron-withdrawing groups at C2.
Nucleophile-directed selective transformation of cis-1-tosyl-2-tosyloxymethyl-3-(trifluoromethyl)aziridine into aziridines, azetidines, and benzo-fused dithianes, oxathianes, dioxanes, and…
- Sara Kenis, M. D’hooghe, N. de Kimpe
- ChemistryChemistry
- 3 May 2013
A five-step procedure for the synthesis of cis-1-tosyl-2-tosyloxymethyl-3-(trifluoromethyl)aziridine was developed, starting from 1-ethoxy-2,2,2-trifluoroethanol, involving imination, aziridination,…
Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel antimalarial pharmacophores.
- M. D’hooghe, Sara Kenis, N. de Kimpe
- ChemistryEuropean journal of medicinal chemistry
- 1 February 2011
Straightforward synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone.
- Sara Kenis, M. D’hooghe, N. de Kimpe
- ChemistryOrganic and biomolecular chemistry
- 28 September 2011
Novel primary β-iodo amines were obtained by regioselective ring opening of these 2-(trifluoromethyl)aziridines using alkyl iodides, and their synthetic potential was demonstrated by converting them into novel α-CF(3)-β-phenylethylamines upon treatment with lithium diphenylcuprate.
Selective synthesis of functionalized trifluoromethylated pyrrolidines, piperidines, and azepanes starting from 1-tosyl-2-(trifluoromethyl)aziridine.
- Jeroen Dolfen, Sara Kenis, K. Van Hecke, N. de Kimpe, M. D’hooghe
- ChemistryChemistry
- 18 August 2014
This paper reports on the generation and alkylation of the 1-tosyl-2-(trifluoromethyl)aziridin-2-yl anion with ω,ω'-dihaloalkanes, followed by a novel ring-expansion protocol toward…
Synthesis of gem-difluorinated 1,6-naphthyridine-5,7-diones
- Karel Piron, Sara Kenis, N. Kimpe
- Chemistry
- 26 August 2012
Synthesis of 1‐Alkyl‐2‐(trifluoromethyl)azetidines and Their Regiospecific Ring Opening Toward Diverse α‐(Trifluoromethyl)amines via Intermediate Azetidinium Salts.
- Sara Kenis, M. D’hooghe, G. Verniest, Tuyet Anh Dang Thi, T. V. Nguyen, N. Kimpe
- Chemistry
- 27 November 2012
The title compounds undergo regiospecific ring opening at C-4 by treatment with nitrogen, sulfur, carbon, oxygen, and halogen nucleophiles.
Synthesis of Trifluoromethylated Azetidines, Aminopropanes, 1,3-Oxazinanes, and 1,3-Oxazinan-2-ones Starting from 4-Trifluoromethyl-β-lactam Building Blocks.
- Hang Dao Thi, L. Decuyper, M. D’hooghe
- Chemistry
- 1 August 2016
The Effects of Exoskeleton-Assisted Overground Gait Training in Chronic Stroke – A Pilot Study
- Jonas Schröder, Sara Kenis, Kris Goos, S. Truijen, W. Saeys
- Psychology, MedicineConverging Clinical and Engineering Research on…
- 16 October 2018
This is a pilot study into the feasibility and effectiveness of robot-assisted gait training (RAGT) provided with a mobile exoskeleton for overground walking practice and clinical relevant improvements in walking ability were observed in the RAGT group only.
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