Sara K. Herrera

Learn More
Parkinson's disease (PD) is a common neurodegenerative disorder that results from the selective loss of midbrain dopaminergic neurons. Misfolding and aggregation of the protein alpha-synuclein, oxidative damage, and proteasomal impairment are all hypotheses for the molecular cause of this selective neurotoxicity. Here, we describe a Saccharomyces cerevisiae(More)
Parkinson's disease (PD) is a common neurodegenerative disorder that results from the selective loss of midbrain dopaminergic neurons. Misfolding and aggregation of the protein α-synuclein, oxidative damage, and proteasomal impairment are all hypotheses for the molecular cause of this selective neurotoxicity. Here, we describe a Saccharomyces cerevisiae(More)
In Parkinson's disease (PD), misfolded and aggregated α-synuclein protein accumulates in degenerating midbrain dopaminergic neurons. The amino acid alanine-76 in α-synuclein and phosphorylation at serine-87 and serine-129 are thought to regulate its aggregation and toxicity. However, their exact contributions to α-synuclein membrane association are less(More)
In Parkinson's disease (PD), midbrain dopaminergic neuronal death is linked to the accumulation of aggregated α-synuclein. The familial PD mutant form of α-synuclein, E46K, has not been thoroughly evaluated yet in an organismal model system. Here, we report that E46K resembled wild-type (WT) α-synuclein in Saccharomyces cerevisiae in that it predominantly(More)
Parkinson’s disease is a neurodegenerative disorder that is caused by the loss of dopaminergic neurons in the substantia nigra. Misfolding of αsynuclein is thought to cause this selective cell death. In our α-synuclein yeast overexpression model, we previously demonstrated that α synuclein, is non-toxic to yeast, runs 8-10 kDa higher on protein gels and(More)
Follow this and additional works at: http://publications.lakeforest.edu/eukaryon Part of the Cell and Developmental Biology Commons, and the Molecular and Cellular Neuroscience Commons Disclaimer: Eukaryon is published by students at Lake Forest College, who are solely responsible for its content. The views expressed in Eukaryon do not necessarily reflect(More)
  • 1