Sara Jane Agee

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Cardiotoxicity was an unanticipated side effect elicited by the clinical use of imatinib (Imb). This toxicity has been examined in only a limited number of experimental studies. The present study sought, by a variety of approaches, to identify important characteristics of Imb-induced cardiac alterations. Male spontaneously hypertensive rats (SHRs) received(More)
IL-13 is a Th2 cytokine that has been shown to be an important mediator of airway inflammation contributing to asthma lesions. Given its proposed role in asthma, measurements of this cytokine in serum may provide insights into disease mechanisms, progression and pharmacodynamic effects of IL-13 targeted therapeutics. However, current commercially available(More)
The gene nanos (nos) is a maternal posterior group gene required for normal development of abdominal segments and the germ line in Drosophila. Expression of nos-related genes is associated with the germ line in a broad variety of other taxa, including the leech Helobdella robusta, where zygotically expressed Hro-nos appears to be associated with primordial(More)
Serum cardiac troponin-I has been validated as a biomarker for cardiotoxicity in numerous animal models; however, baseline reference ranges for cTnI concentration in a healthy population of laboratory rats, as well as an investigation of biological cTnI variability in rats with respect to time, handling, and placebo dosing methods, have not been reported.(More)
0.001] (Fig. 1). The patients in the nonhealed group also had lower mean (SD) bALP concentrations than the patients in the healed group [33.15 (1.43) vs 82.32 (13.73) U/L, P 0.001]. The clinical and radiographic scores were significantly lower in the nonhealed group than in the healed group, and this difference was most pronounced at 3 months. It has been(More)
Cardiac troponins have proved to be reliable blood biomarkers for identifying a variety of myocardial alterations in humans and animals. Recently, an ultrasensitive cTnI assay (Erenna IA) has been used to demonstrate increases in baseline cTnI resulting from drug-induced myocardial injury in rats, dogs, and monkeys, as well as to document baseline cTnI(More)
Cardiac troponin I (cTnI) is the gold standard biomarker for diagnosing patients with acute coronary syndromes. Expert panels have defined the decision limit at 99th percentile of a reference population and assay imprecision of 10%. Prototype ultrasensitive cTnI assays allow accurate detection of low concentrations of cTnI in healthy individuals. However,(More)
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