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Studies using animal models have been unable to determine the mechanical stimuli that most influence muscle architectural adaptation. We examined the influence of contraction mode on muscle architectural change in humans, while also describing the time course of its adaptation through training and detraining. Twenty-one men and women performed slow-speed(More)
The frequencies of GC phenotypes in 104 patients with chronic obstructive airways disease (COAD) were compared with those in 413 control subjects. The distributions were significantly different with fewer patients with the GC 2 allele than expected (relative risks = 0.8, 0.7 and 0.5 for 2-2, 2-1S and 2-1F, respectively) and more 1F-1F patients than expected(More)
BACKGROUND Obesity increases the risk of cardiovascular disease, hypertension, diabetes, digestive diseases, and some cancers. Several studies have shown that excess weight or weight gain is related to pulmonary dysfunction, but this issue needs to be further clarified. METHODS The analysis was based on data of the Humboldt cohort study which was(More)
This study examined the effects of slow-speed resistance training involving concentric (CON, n = 10) versus eccentric (ECC, n = 11) single-joint muscle contractions on contractile rate of force development (RFD) and neuromuscular activity (EMG), and its maintenance through detraining. Isokinetic knee extension training was performed 3 x week(-1) for 10(More)
The most important anatomical determinants of in vivo joint moment magnitude have yet to be defined. Relationships between maximal knee extensor moment and quadriceps muscle volume, anatomical (ACSA) and physiological (PCSA) cross-sectional area, muscle architecture and moment arm (MA) were compared. Nineteen untrained men and women performed maximal(More)
The relationships of bodyweight and body mass index with smoking cessation were examined among 1633 adults in Humboldt, Saskatchewan, Canada. Mean body mass index was highest in ex-smokers and lowest in smokers, and that of non-smokers was intermediate. Body mass index decreased significantly with increasing years after smoking cessation in female(More)
The interaction between sex and smoking habits on pulmonary function was examined among 1,149 adults 25 to 59 yr of age in a rural community in Saskatchewan. Pulmonary function tests included FVC, FEV1, maximal midexpiratory flow rate (MMFR), the slope of phase III of the single-breath nitrogen test (delta N2/L), and closing volume as a percent of vital(More)
Changes in contractile rate of force development (RFD), measured within a short time interval from contraction initiation, were measured after a period of strength training that led to increases in muscle fascicle length but no measurable change in neuromuscular activity. The relationship between training-induced shifts in the moment-angle relation and(More)
Maximum power production during multi-joint tasks increases as children grow older. Previous research suggests that in adults, maximum power production in jumping is related to lower limb stiffness. In a developmental context, the question arises as to whether the relationship between maximum power production and lower limb stiffness is age-dependent. The(More)
The Humboldt Family Study was conducted in the town of Humboldt, Saskatchewan, in 1993. Familial correlations and segregation analyses of lung function were carried out in 799 individuals in 214 nuclear families that included 214 fathers, 214 mothers, and 371 children. Forced expiratory volume in 1 second (FEV1) and maximal mid-expiratory flow rate (MMFR)(More)