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BACKGROUND Pediatric anxiety disorders, although highly prevalent, are understudied with little known about their pathophysiology. Intolerance of uncertainty (IU) is a trait associated with worry, a key characteristic of these disorders. Neural responses to uncertainty in healthy subjects involve the same frontal-limbic circuits that are hyper-responsive in(More)
BACKGROUND Maturation of prefrontal circuits during adolescence contributes to the development of cognitive processes such as decision-making. Recent theories suggest that these neural changes also play a role in the shift from generalized anxiety disorder (GAD) to depression that often occurs during this developmental period. Cognitive models of the(More)
The suprachiasmatic nucleus (SCN) has several structural characteristics and cell phenotypes shared across species. Here, we describe a novel feature of SCN anatomy that is seen in both hamster and mouse. Frozen sections through the SCN were obtained from fixed brains and stained for the presence of immunoreactivity to neuronal nuclear protein (NeuN-IR)(More)
To cite: Hefton S, Bogush N, Crawford RS, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015210274 DESCRIPTION Awoman in her 70s was found lying prone, with an ST-elevation myocardial infarction and in cardiogenic shock. She was obtunded, answering ‘No’ to all questions, and was observed to have anisocoria with a(More)
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