Sara G.I. Suliman

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CONTEXT Macroprolactinomas (MPRLs) may result in nonsurgical (spontaneous or dopamine agonist induced) cerebrospinal fluid (CSF) rhinorrhea; however, the incidence of and mechanisms underlying this phenomenon are poorly understood. OBJECTIVE The objective of the study was to determine the incidence of nonsurgical rhinorrhea and identify biochemical,(More)
OBJECTIVE Digenic causes of human disease are rarely reported. Insulin via its receptor, which is encoded by INSR, plays a key role in both metabolic and growth signaling pathways. Heterozygous INSR mutations are the most common cause of monogenic insulin resistance. However, growth retardation is only reported with homozygous or compound heterozygous(More)
The proband was initiated on insulin therapy for diabetes from the age of 15 years. She has required variable insulin dosage. Notably, requiring less insulin throughout pregnancy and dietary treatment alone for 2 months post-natally and she is currently managed with gradually increasing insulin doses. The substantial reduction in insulin requirement is at(More)
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