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Decidual Neutrophil Infiltration Is Not Required for Preterm Birth in a Mouse Model of Infection-Induced Preterm Labor
Parturition is associated with a leukocyte influx into the intrauterine tissues; however, the exact role these leukocytes play in the onset of labor remains unclear. Neutrophil infiltration of theExpand
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Anti-inflammatory mediators as physiological and pharmacological regulators of parturition
Increasing evidence highlights parturition as an inflammatory event characterized by leukocyte influx and proinflammatory mediator production in the intrauterine environment. While the mechanismsExpand
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Repurposing simvastatin as a therapy for preterm labor: evidence from preclinical models
Preterm birth (PTB), the leading cause of neonatal morbidity and mortality, urgently requires novel therapeutic agents. Spontaneous PTB, resulting from preterm labor, is commonly caused byExpand
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Androgen-Induced Relaxation of Uterine Myocytes Is Mediated by Blockade of Both Ca(2+) Flux and MLC Phosphorylation.
CONTEXT Uterine quiescence must be maintained until pregnancy reaches term. Premature activation of myometrial contractility leads to preterm labor and delivery. OBJECTIVE To scrutinize theExpand
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The preterm cervix reveals a transcriptomic signature in the presence of premature prelabor rupture of membranes
BACKGROUND: Premature prelabor rupture of fetal membranes accounts for 30% of all premature births and is associated with detrimental long‐term infant outcomes. Premature cervical remodeling,Expand
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Ultrasound-guided intrauterine injection of lipopolysaccharide as a novel model of preterm birth in the mouse.
Mouse models are used to study mechanisms that link intrauterine infection and preterm birth (PTB). To mimic intrauterine infection, lipopolysaccharide (LPS) is commonly injected into the uterus viaExpand
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Expression of Matrix Metalloproteinases in the Mouse Uterus and Human Myometrium During Pregnancy, Labor, and Preterm Labor
Background: Uterine extracellular matrix (ECM) remodeling occurs throughout pregnancy and at parturition. Imbalanced availability of key mediators in ECM degradation, namely, matrixExpand
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Statin treatment in a novel infection-induced mouse model of preterm birth
Results: Co-culture of explants with T cells results in a trend towards reduced system A activity. Syncytial function, assessed by hCG production, was unaffected by culture with immune cells.Expand
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11β-hydroxysteroid dehydrogenase type 1 and pregnancy: Role in the timing of labour onset and in myometrial contraction
Glucocorticoids play a primary role in the maturation of fetal organs and may contribute to the onset of labour. Glucocorticoid activity depends on the 11β-hydroxysteroid dehydrogenase familyExpand
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